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秀丽隐杆线虫对不同氧浓度的应答及其调控机制研究进展

贺娉¹, 康娜¹, 娄萍萍¹, 涂海军^1,2,*

¹湖南大学生物学院神经科学研究所，长沙 410082；²湖南大学深圳研究院，深圳 518000

摘要

不同地理位置的人类生活环境中氧气水平不同，与人体的正常生理功能密切相关。体内氧气的减少会引发多种疾病，如大脑缺血、缺氧导致的脑卒中。近年来利用秀丽隐杆线虫(Caenorhabditis elegans，简称线虫)作为模式生物研究机体对不同氧浓度应答和调控机制取得了长足进展。研究表明，线虫会逃避氧浓度过高或过低的环境，并对周围氧气浓度的变化有适应性，而且其在不同程度低氧环境中存在不同的应答与调控机制。本文综述了近年来线虫对不同氧气浓度的反应和调控机制研究进展。

关键词： 秀丽隐杆线虫; 氧气浓度; 低氧/无氧; 敏感与耐受; 缺血性脑卒中

分类号：Q95-337; Q955

Progress in the mechanisms of response to different oxygen concentrations in Caenorhabditis elegans

HE Ping¹, KANG Na¹, LOU Ping-Ping¹, TU Hai-Jun^1,2,*

¹Institute of Neuroscience, College of Biology, Hunan University, Changsha 410082, China；²Shenzhen Research Institute, Hunan University, Shenzhen 518000, China

Abstract

Oxygen levels are unequal in different living geographical locations of human and related to normal physiology of health. The reduction of oxygen level in the body can lead to a variety of diseases, such as stroke caused by cerebral ischemia and hypoxia. In the recent years, many studies have elucidated the molecular and cellular mechanisms of organism response to different oxygen concentrations by using the nematode Caenorhabditis elegans (C. elegans) as model organism. C. elegans can escape hypoxia or hyperoxia and adapt to the ambient oxygen environments, and there are different response and regulation mechanisms in different degrees of hypoxia environment. In this paper, recent advances in the reaction of nematodes to different oxygen concentrations and the underlying mechanism were reviewed. 

Key words: Caenorhabditis elegans; oxygen concentrations; hypoxia/anoxia; sensitivity and tolerance; cerebral ischemia

收稿日期：2019-04-07　　录用日期：2019-05-13

通讯作者：涂海军　　E-mail: haijuntu@hnu.edu.cn

DOI: 10.13294/j.aps.2020.0027

引用本文：

贺娉, 康娜, 娄萍萍, 涂海军. 秀丽隐杆线虫对不同氧浓度的应答及其调控机制研究进展[J]. 生理学报 2020; 72 (3): 407-417.

HE Ping, KANG Na, LOU Ping-Ping, TU Hai-Jun. Progress in the mechanisms of response to different oxygen concentrations in Caenorhabditis elegans. Acta Physiol Sin 2020; 72 (3): 407-417 (in Chinese with English abstract).