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应激对肠道菌群的影响及机制研究进展

宋立锦, 张晋东, 段丽萍^*

北京大学第三医院消化科，北京 100191

摘要

应激是机体受到各种因素刺激时所出现的全身非特异性反应，可对全身各个系统产生影响。肠道菌群是肠道微生态的重要组成部分，对维持机体健康发挥重要作用。应激通过影响肠道黏膜屏障功能、肠道免疫功能、胃肠道运动功能等引起肠道菌群紊乱。本文就应激对肠道菌群的影响及机制的研究进展进行综述。

关键词： 应激; 肠道菌群; 益生菌

分类号：R338

Progresses on the effects and mechanisms of stress on gut microbiota

SONG Li-Jin, ZHANG Jin-Dong, DUAN Li-Ping^*

Department of Gastroenterology, Peking University Third Hospital, Beijing 100191, China

Abstract

Stress is the non-specific systemic response that occurs when the body is stimulated by various factors, and it can affect multiple systems of the body. Recent studies have shown that gut microbiota is an essential part of human microecology, and plays a pivotal role in keeping the body healthy. Stress can result in gut dysbiosis by affecting the function of intestinal mucosal barrier, intestinal immune and gastrointestinal motility. This article reviewed the alteration of gut microbiota caused by stress and the possible mechanisms involved.

Key words: Stress; gut microbiota; probiotics

收稿日期：2019-10-23　　录用日期：2020-01-02

通讯作者：段丽萍　　E-mail: duanlp@bjmu.edu.cn

DOI: 10.13294/j.aps.2020.0031

引用本文：

宋立锦, 张晋东, 段丽萍. 应激对肠道菌群的影响及机制研究进展[J]. 生理学报 2020; 72 (3): 361-370.

SONG Li-Jin, ZHANG Jin-Dong, DUAN Li-Ping. Progresses on the effects and mechanisms of stress on gut microbiota. Acta Physiol Sin 2020; 72 (3): 361-370 (in Chinese with English abstract).