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肾上腺素能受体在脑胶质瘤发生和发展中作用的研究进展

贺烨¹, 朱瑜格², 刘伟柱³, 张文华³, 潘秉兴³, 胡萍^2,*

¹南昌大学医学部医学实验教学中心，南昌 330031；²南昌大学转化医学研究院生物技术与生物诊疗药物研发中心，南昌 330031；³南昌大学生命科学研究院恐惧与焦虑障碍研究室，南昌 330031

摘要

脑胶质瘤是侵袭能力极强的恶性肿瘤，目前治疗策略主要是手术治疗辅助放射治疗、化学治疗和免疫治疗等多种治 疗，但疗效有限。肾上腺素能受体(adrenergic receptor, AR)是体内一种重要的应激激素受体，AR通过激活下游不同信号转导 通路广泛参与调节多种肿瘤的发生与发展进程。最近研究显示，AR在脑胶质瘤细胞以及组织中表达失调，在脑胶质瘤的发 生、侵袭和转移等一系列生物学行为中发挥着重要作用。本文对近年来AR在脑胶质瘤发生和发展中的研究进展进行综述， 为以AR为靶点的脑胶质瘤的预防和治疗提供理论依据。

关键词： 脑胶质瘤; 肾上腺素能受体; 应激; 肿瘤生长

分类号：R739.4;Q26

Role of adrenergic receptors in tumorigenesis and development of glioma

HE Ye¹, ZHU Yu-Ge², LIU Wei-Zhu³, ZHANG Wen-Hua³, PAN Bing-Xing³, HU Ping^2,*

¹Center for Basic Medical Experiment, Nanchang University, Nanchang 330031, China；²The Center for Biotechnology and Biopharmaceutics, Institute of Translational Medicine, Nanchang University, Nanchang 330031, China；³Laboratory of Fear and Anxiety Disorders, Institute of Life Science, Nanchang University, Nanchang 330031, China

Abstract

Gliomas are malignant tumors with strong invasiveness. The current treatment strategy is surgical treatment assisted by a variety of radiotherapies, chemotherapies and immunotherapies. However, the curative efficacy is limited. Adrenergic receptor (AR) is an important stress hormone receptor, which is highly involved in the regulation of the tumorigenesis and progression of various tumors by activating different downstream signal transduction pathways. Recent studies have shown that AR is dysregulated in glioma cells and tissues, and plays an important role in a series of biological behaviors such as tumorigenesis, invasion and metastasis of glioma. This article reviews the research progress of AR in the field of glioma in recent years, which provides a theoretical basis for the prevention and treatment of glioma targeting the AR.

Key words: glioma; adrenergic receptor; chronic stress; tumor growth

收稿日期：2019-08-24　　录用日期：2020-01-02

通讯作者：胡萍　　E-mail: canyhp@163.com

DOI: 10.13294/j.aps.2020.0011

引用本文：

贺烨, 朱瑜格, 刘伟柱, 张文华, 潘秉兴, 胡萍. 肾上腺素能受体在脑胶质瘤发生和发展中作用的研究进展[J]. 生理学报 2020; 72 (2): 235-242.

HE Ye, ZHU Yu-Ge, LIU Wei-Zhu, ZHANG Wen-Hua, PAN Bing-Xing, HU Ping. Role of adrenergic receptors in tumorigenesis and development of glioma. Acta Physiol Sin 2020; 72 (2): 235-242 (in Chinese with English abstract).