过刊浏览

肾上腺素能受体信号调控巨噬细胞参与疾病微环境的研究进展

王吉菊¹, 李大金^1,2,3, 杜美蓉^1,2,3,*

¹复旦大学附属妇产科医院研究所生殖免疫实验室，上海 200011；²国家人口和计划生育委员会计划生育药具重点实验室，上 海 200032；³上海市女性内分泌相关疾病重点实验室，上海 200011

摘要

肾上腺素能受体(adrenergic receptors, ARs)作为神经系统功能调控的关键受体之一，在多种疾病的免疫微环境形成以 及疾病进展中扮演重要角色。近年来ARs及其信号对巨噬细胞功能的调控成为研究热点。在不同疾病微环境中，ARs通过对 巨噬细胞的分化与发育发挥不同的调节功能，进而影响肿瘤、肥胖、急性损伤与感染性疾病、心力衰竭以及妊娠相关疾病 的发生和发展。本文从ARs的分型及激活途径，ARs在巨噬细胞的表达、功能调控及在不同疾病微环境中的作用等方面进行 综述，以期为相关疾病的干预和治疗提供新思路。

关键词： 肾上腺素能受体; 巨噬细胞; 功能调控; 疾病微环境

分类号：R339.2

Research advances on adrenergic receptor signaling involved in disease microenvironment through regulation of macrophages

WANG Ji-Ju¹, LI Da-Jin^1,2,3, DU Mei-Rong^1,2,3,*

¹Laboratory for Reproductive Immunology, Hospital of Obstetrics and Gynecology, Fudan University, Shanghai 200011, China；²Key Laboratory of Reproduction Regulation of National Population and Family Planning Commission (NPFPC), Shanghai 200032, China；³Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai 200011, China

Abstract

Adrenergic receptor (AR), one of the key receptors for nervous system, plays an important role in the immune microenvironment and the progression of many diseases. In recent years, the regulation of ARs and its signal on macrophages has become a research hotspot. Researchers found that ARs could exert different regulatory functions on macrophages in different microenvironments, which in turn affects occurrence and development of diseases such as tumor, heart failure, obesity, acute injury, infection and pregnancy-related diseases. This review summarizes the expression and functional regulation of ARs on macrophages, and the role of ARs in microenvironment of related diseases, which might provide new ideas for the treatments.

Key words: adrenergic receptors; macrophages; functional regulation; microenvironment of related diseases

收稿日期：2019-08-28　　录用日期：2020-02-13

通讯作者：杜美蓉　　E-mail: mrdu@ fudan.edu.cn

DOI: 10.13294/j.aps.2020.0010

引用本文：

王吉菊, 李大金, 杜美蓉. 肾上腺素能受体信号调控巨噬细胞参与疾病微环境的研究进展[J]. 生理学报 2020; 72 (2): 227-234.

WANG Ji-Ju, LI Da-Jin, DU Mei-Rong. Research advances on adrenergic receptor signaling involved in disease microenvironment through regulation of macrophages. Acta Physiol Sin 2020; 72 (2): 227-234 (in Chinese with English abstract).