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运动调控线粒体呼吸链超级复合体的研究进展

王艳^1,2, 薄海^3,2, 张勇^2,*

¹北京体育大学运动人体科学学院，北京 100084；²天津体育学院运动与健康研究 院，天津市运动生理学与运动医学重点实验室，天津 310617；³武警后勤学院卫生勤务系，天津 300162

摘要

线粒体呼吸链超级复合体(mitochondrial respiratory chain supercomplex, mitoSC)是线粒体内膜呼吸链上的自由复合体 通过其亚基之间的相互作用形成的复合体超级组装，主要为mitoSCI1+III2+IV1-4、mitoSCI1+III2、mitoSCIII2+IV1-2、高分子量 mitoSC (high molecular weight mitoSC, HMW mitoSC)和巨型超级复合体(mitochondrial metacomplex, mitoMC)。mitoSC已被证 明具有提高呼吸链电子传递效率、减少活性氧产生的功能。在衰老的不同组织和诸多线粒体相关疾病组织中，mitoSC的种 类和含量发生变化。本文通过归纳人类和哺乳动物不同组织中mitoSC的结构和功能，总结衰老、心脏疾病、2型糖尿病、癌 症和基因缺陷疾病等条件下mitoSC的变化规律，重点探讨运动对mitoSC的影响及其相关调节机制，为线粒体相关疾病的运 动干预提供参考。

关键词： 线粒体呼吸链超级复合体; 运动; 活性氧; 电子传递; 线粒体相关疾病

分类号：R332;R363.2;R329.2

Research progress in regulation of exercise on mitochondrial respiratory chain supercomplex

WANG Yan^1,2, BO Hai^3,2, ZHANG Yong^2,*

¹School of Sports Science, Beijing Sport University, Beijing 100084, China；²Tianjin Key Laboratory of Exercise Physiology and Sports Medicine, Research Center for Exercise & Health Science, Tianjin University of Sport, Tianjin 310617, China；³Department of Military Training Medicines, Logistics University of Chinese People’s Armed Police Force, Tianjin 300162, China

Abstract

The mitochondrial respiratory chain supercomplex (mitoSC) is a complex super-assembly formed by free complexes on the mitochondrial inner membrane respiratory chain through the interaction between their subunits, mainly including mitoSCI1+III2+IV1-4, mitoSCI1+III2, mitoSCIII2+IV1-2, high molecular weight mitoSC (HMW mitoSC) and mitochondrial metacomplex (mitoMC). mitoSC has been shown to improve the efficiency of electron transport in the respiratory chain and reduce the production of reactive oxygen species. The species and content of mitoSC change in different tissues in aging and many mitochondria-related diseases. By summarizing the structure and function of mitoSC in different tissues of human and mammals, and the changes of mitoSC under conditions of aging, heart disease, type 2 diabetes, cancer and genetic defects, this review focuses on the effects of exercise on mitoSC and its related regulation mechanisms in order to offer an insight for exercise interventions in mitochondria-related diseases.

Key words: mitochondrial respiratory chain supercomplex; exercise; reactive oxygen species; electron transport; mitochondria-related diseases

收稿日期：2019-08-26　　录用日期：2020-02-13

通讯作者：张勇　　E-mail: yzhang@tjus.edu.cn

DOI: 10.13294/j.aps.2020.0016

引用本文：

王艳, 薄海, 张勇. 运动调控线粒体呼吸链超级复合体的研究进展[J]. 生理学报 2020; 72 (2): 205-219.

WANG Yan, BO Hai, ZHANG Yong. Research progress in regulation of exercise on mitochondrial respiratory chain supercomplex. Acta Physiol Sin 2020; 72 (2): 205-219 (in Chinese with English abstract).