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Kisspeptin在女性生殖内分泌和辅助生殖技术中的研究进展

章翊, 孙宁霞^*

海军军医大学第二附属医院生殖医学中心，上海 200003

摘要

近年来研究显示，kisspeptin在大脑的性别分化、性激素正负反馈调节、青春期始动以及机体能量信号转导等生理过 程中起到重要作用，表明 kisspeptin可能是女性生殖功能成熟及调控的一个关键性信号因子。除下丘脑分泌的kisspeptin之 外，生殖器官局部表达的kisspeptin 在机体正常生殖过程中的作用也不断得到证实。研究表明，很多生殖内分泌疾病，如单 纯性促性腺激素分泌不足的性腺机能减退症 (isolated hypogonadotropic hypogonadism, IHH)、多囊卵巢综合征(polycystic ovary syndrome, PCOS)、卵巢早衰(premature ovarian failure, POF)、病理性高泌乳素血症等，都与kisspeptin的异常表达有关。通过 给予外源性 kisspeptin可解决辅助生殖技术应用中的一些问题。本文主要就 kisspeptin在女性生殖内分泌尤其是在辅助生殖领 域研究中所取得的进展进行论述。

关键词： kisspeptin; 生殖生理; 女性不孕症; 辅助生殖技术

分类号：R399.2;R711.6;R363.2

Research progress of kisspeptin in female reproductive endocrine and assisted reproductive techniques

ZHANG Yi, SUN Ning-Xia^*

Reproductive Medicine Center, the Second Affiliated Hospital of Naval Military Medical University, Shanghai 200003, China

Abstract

In recent years, it has been found that kisspeptin plays some key roles in the physiological processes of the brain, such as gender differentiation, positive and negative feedback of sex hormones, onset of puberty, and transduction of energy signals in the body, which suggests that kisspeptin may be a key molecule for the maturation and regulation of female reproductive function. In addition to the systemic roles of the kisspeptin, its local roles in reproductive organs are constantly being discovered. With the discovery that kisspeptin is involved in the pathological process of reproductive endocrine diseases such as isolated hypogonadotropic hypogonadism (IHH), polycystic ovary syndrome (PCOS), premature ovarian failure (POF) and pathological hyperprolactinemia, exogenous application of kisspeptin to solve reproductive problems has become a new hot topic. The review focuses on the research progress of kisspeptin in the female reproductive system, especially on its application in assisted reproduction.

Key words: kisspeptin; reproductive physiological phenomena; infertility, female; reproductive techniques, assisted

收稿日期：2019-08-05　　录用日期：2020-01-02

通讯作者：孙宁霞　　E-mail: suesunchzh@126.com

DOI: 10.13294/j.aps.2020.0008

引用本文：

章翊, 孙宁霞. Kisspeptin在女性生殖内分泌和辅助生殖技术中的研究进展[J]. 生理学报 2020; 72 (1): 125-132.

ZHANG Yi, SUN Ning-Xia. Research progress of kisspeptin in female reproductive endocrine and assisted reproductive techniques. Acta Physiol Sin 2020; 72 (1): 125-132 (in Chinese with English abstract).