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胚胎植入的调控机理

郭斌^*

吉林大学动物医学学院，长春 130062

摘要

胚胎植入对于妊娠的建立和维持至关重要，需要活化的胚泡和接受态的子宫之间进行同步。在辅助生殖技术中，子 宫接受态的判断仍是制约妊娠率的一个关键限制性因素。已有数据显示，胚胎植入涉及一系列信号分子的激活和失活，进 而影响子宫腔上皮细胞的增殖与分化、上皮极性、宫腔闭合、胚胎定位、上皮基质反应、腺体发育等。本文就雌激素、孕 酮、白血病抑制因子(leukemia inhibitory factor, LIF)、microRNA (miRNA)、通道蛋白、信号转导通路等在胚胎植入过程中的 作用及其调控网络作一综述，以期为不孕症的治疗及安全有效的避孕药开发提供理论依据。

关键词： 子宫接受态; 胚胎植入; 调控机理

分类号：Q492.6;S852.1

Regulatory mechanism of embryo implantation

GUO Bin^*

College of Veterinary Medicine, Jilin University, Changchun 130062, China

Abstract

Embryo implantation is crucial for the establishment and maintenance of successful pregnancy and requires the synchronization between implantation-competent blastocyst and receptive uterus. In assisted reproductive technologies, recognition of uterine receptivity is the limiting factor for improving pregnancy rate. It has been previously reported that embryo implantation involves the activation and inactivation of numerous signaling molecules which may influence the proliferation and differentiation of uterine epithelial cells, epithelial polarity, luminal closure, embryo orientation, epithelial-stromal interactions, gland development, etc. Here we summarize the function of estrogen, progesterone, leukemia inhibitory factor (LIF), microRNA (miRNA), channel protein and signaling pathways in embryo implantation and explore their regulatory network to provide theoretical basis for the treatment of infertility and development of safe and efficient contraceptives.

Key words: uterine receptivity; embryo implantation; regulatory mechanism

收稿日期：2019-07-15　　录用日期：2019-11-25

通讯作者：郭斌　　E-mail: guobin79@jlu.edu.cn

DOI: 10.13294/j.aps.2020.0005

引用本文：

郭斌. 胚胎植入的调控机理[J]. 生理学报 2020; 72 (1): 105-114.

GUO Bin. Regulatory mechanism of embryo implantation. Acta Physiol Sin 2020; 72 (1): 105-114 (in Chinese with English abstract).