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母-胎界面T细胞功能研究进展

黄茜茜¹, 刘璐^1,2, 王莉^1,2,3, 杜美蓉^1,4,2,*

¹复旦大学附属妇产科医院研究所，上海 200011；²上海市女性内分泌相关疾病重点实验室，上海 200011；³复旦大学附属妇产科医院中西医结合科，上海 200011；⁴国家人口和计划生育委员会计划生育药具重点实验室，上海 200032

摘要

母-胎界面免疫耐受是成功妊娠建立和维持的基础，T细胞是子宫蜕膜免疫细胞的重要组成细胞，既要介导抗感染免 疫，保护胚胎免遭外来病原体攻击，同时又要参与母体接受同种异体胚胎的复杂免疫调节过程，在调控胚胎植入和维持妊 娠过程中发挥重要作用，其功能失调可能会导致早期妊娠失败或中晚期妊娠并发症。本文就近年来关于妊娠期母-胎界面T 细胞亚群的组成、表型特征及其功能进行介绍，并进一步阐述蜕膜CD4+与CD8+ T细胞在母-胎免疫调节中的作用，以及异常 调控致早期妊娠失败的分子机制，有助于深入理解母-胎免疫耐受机制，为妊娠相关疾病的防治提供新的线索。  

关键词： T细胞; 母-胎界面; 母-胎免疫耐受; 妊娠相关疾病

分类号：R392.1; R711.6

Research advances in the function of T cells at the maternal-fetal interface

HUANG Xi-Xi¹, LIU Lu^1,2, WANG Li^1,2,3, DU Mei-Rong^1,4,2,*

¹Institute of Obstetrics and Gynecology, Hospital of Obstetrics and Gynecology, Fudan University, Shanghai 200011, China；²Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai 200011, China；³Department of Integrated Traditional and Western Medicine, Hospital of Obstetrics and Gynecology, Fudan University, Shanghai 200011, China；⁴Key Laboratory of Reproduction Regulation of the National Population and Family Planning Commission (NPFPC), Shanghai 200032, China

Abstract

Immune tolerance at maternal-fetal interface is the basis for establishment and maintenance of successful pregnancy. T cells are pivotal compositions of uterine decidual immune cells, which are required to mediate anti-infection immunity and protect embryos from external antigens attack. T cells also participate in the complex immune regulation process of maternal acceptance of semi-allogeneic embryos, and play an important role in regulating embryo implantation and maintaining pregnancy. Its dysfunction may lead to early pregnancy failures or mid-late pregnancy complications. This review summarizes the compositions, phenotypic characteristics and functions of decidual T cells at the maternal-fetal interface in recent years, and further describes the regulation of decidual CD4+ and CD8+ T cells in maternal-fetal immune tolerance as well as the molecular mechanisms of abnormal regulation leading to early pregnancy failures. Through the in-depth understanding the mechanism of maternal-fetal immune regulation, it supplies a novel concept on maternal-fetal immune tolerance and new clues for the immunotherapy of pregnancy-related diseases.

Key words: T cells; maternal-fetal interface; maternal-fetal tolerance; pregnancy complications

收稿日期：2019-07-04　　录用日期：2019-09-25

通讯作者：杜美蓉　　E-mail: mrdu@fudan.edu.cn

DOI: 10.13294/j.aps.2019.0080

引用本文：

黄茜茜, 刘璐, 王莉, 杜美蓉. 母-胎界面T细胞功能研究进展[J]. 生理学报 2020; 72 (1): 11-19.

HUANG Xi-Xi, LIU Lu, WANG Li, DU Mei-Rong. Research advances in the function of T cells at the maternal-fetal interface. Acta Physiol Sin 2020; 72 (1): 11-19 (in Chinese with English abstract).