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2019年诺贝尔生理学医学奖：机体细胞感受氧变化及适应性反应的机制

郝传明^*, 李菁

复旦大学肾脏病研究所，复旦大学附属华山医院肾病科，上海 200040

摘要

编者按：继上期，本刊又邀请我国低氧研究领域的专家撰文，简述2019年诺贝尔生理学或医学奖获得者发现细胞如何感知和适应氧浓度变化的研究，探讨低氧诱导因子(HIF)信号通路对相关生理及病理生理过程的认识和对疾病干预靶点的意义，以及HIF通路发现的成功转化——HIF-PHD抑制剂(PHD inhibitor, PHI)治疗肾性贫血。

Nobel Prize in Physiology and Medicine, 2019: Mechanism of changes in oxygen and adaptive response in body cell

HAO Chuan-Ming^*, LI Jing

Division of Nephrology, Huashan Hospital, and Nephrology Research Institute, Fudan University, Shanghai 200040, China

Abstract

Editor's note: following the previous issue, we have invited experts in the field of hypoxia research to give a brief review on the 2019 Nobel Prize winner's study, regarding to how cells perceive and adapt to changes in oxygen concentration.

收稿日期：　　录用日期：

通讯作者：郝传明　　E-mail: chuanminghao@fudan.edu.cn

DOI: 10.13294/j.aps.2019.0082

引用本文：

郝传明, 李菁. 2019年诺贝尔生理学医学奖：机体细胞感受氧变化及适应性反应的机制[J]. 生理学报 2019; 71 (6): 946-949.

HAO Chuan-Ming, LI Jing. Nobel Prize in Physiology and Medicine, 2019: Mechanism of changes in oxygen and adaptive response in body cell. Acta Physiol Sin 2019; 71 (6): 946-949 (in Chinese with English abstract).