ISSN 0371-0874, CN 31-1352/Q



吴璐瑶1, 陈嘉卉1, 赖保君2, 胡静初1,2,*

1华南师范大学生命科学学院,广州 510631;2华南师范大学心理学院,广州 510631



关键词: 催产素; 恐惧学习; 恐惧消退; 杏仁核

分类号:R749.053; B845

The effect of oxytocin on fear responses: bidirectional regulation or methodological issues?

WU Lu-Yao1, CHEN Jia-Hui1, LAI Bao-Jun2, HU Jing-Chu1,2,*

1School of Life Sciences, South China Normal University, Guangzhou 510631, China;2School of Psychology, South China Normal University, Guangzhou 510631, China


One of the core symptoms in anxiety disorders is dysregulated fear response. It is crucial for psychologists and neuroscientists to understand how fear responses are enhanced and inhibited. Although oxytocin (OXT) was initially conceived as a prosocial molecule and mammalian neuropeptide that enhances cooperation and trust, later studies showed that it produces modulatory influence on fear responses. Therefore, OXT is now regarded as a promising pharmacological agent to boost treatment response in anxiety disorders. However, the effect of OXT on fear responses have been somewhat complex, and there are some contradictions among animal experiments and human studies. In this article, we summarize recent studies that employed animal models, brain region-specific manipulations and preclinical studies to explore the role of OXT in the acquisition and processing of fear response. We also discuss the methodological differences among these studies and review the potential factors that may contribute to the complicated effect of OXT on fear response. This review will help to promote the potential clinical application of OXT.

Key words: Oxytocin; fear learning; fear extinction; amygdala

收稿日期:2019-03-22  录用日期:2019-09-12

通讯作者:胡静初  E-mail:

DOI: 10.13294/j.aps.2019.0079


吴璐瑶, 陈嘉卉, 赖保君, 胡静初. 催产素对恐惧情绪的作用:双向调节还是方法学问题?[J]. 生理学报 2019; 71 (6): 905-916.

WU Lu-Yao, CHEN Jia-Hui, LAI Bao-Jun, HU Jing-Chu. The effect of oxytocin on fear responses: bidirectional regulation or methodological issues?. Acta Physiol Sin 2019; 71 (6): 905-916 (in Chinese with English abstract).