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有氧运动对免疫系统和自身免疫病的影响研究进展

谢宇^1,2,3, 王军朋^1,3,*

¹河南大学淮河医院转化医学中心，开封 475000；²河南大学体育学院，开封 475000；³河南大学感染与免疫研究所，开封 475000

摘要

自身免疫病是一类病因尚不明确的慢性疾病，具有反复性和难以彻底治愈的特点。有氧运动作为有效的慢性疾病干预手段，对自身免疫病的治疗作用受到了广泛关注。本文综述了近年来关于有氧运动对免疫系统和自身免疫病影响的研究进展，讨论有氧运动对免疫系统的影响和改善自身免疫病的相关机制，指出有氧运动通过影响免疫细胞数量及其功能改善机体免疫内环境稳态，抑制机体系统性炎症反应，进而延缓自身免疫病的发生、发展。

关键词： 有氧运动; 免疫系统; 自身免疫病; 炎症

分类号：R392.12

Advance in effect of aerobic exercise on immune system and autoimmune diseases

XIE Yu^1,2,3, WANG Jun-Peng^1,3,*

¹Translational Medical Center of Huaihe Hospital, Henan University, Kaifeng 475000, China；²College of Physical Education, Henan University, Kaifeng 475000, China；³Institute of Infection and Immunity, Henan University, Kaifeng 475000, China

Abstract

Autoimmune diseases are a kind of chronic diseases with unclear etiology, which has the characteristics of repetition and difficulty to cure completely. Aerobic exercise, as an effective intervention method for chronic diseases, has also received extensive attention in the field of the prevention and treatment of autoimmune diseases. In this paper, the effects of aerobic exercise on immune system and autoimmune diseases in recent years are reviewed, and the related mechanisms are discussed. It is pointed out that aerobic exercise can improve the homeostasis of immune environment by affecting the number and function of immune cells, inhibit the systemic inflammatory response of the body, and then delay the occurrence and development of autoimmune diseases. 

Key words: aerobic exercise; immunity; autoimmune diseases; inflammation

收稿日期：2019-02-21　　录用日期：2019-05-14

通讯作者：王军朋　　E-mail: jpwangchina@henu.edu.cn

DOI: 10.13294/j.aps.2019.0062

引用本文：

谢宇, 王军朋. 有氧运动对免疫系统和自身免疫病的影响研究进展[J]. 生理学报 2019; 71 (5): 769-782.

XIE Yu, WANG Jun-Peng. Advance in effect of aerobic exercise on immune system and autoimmune diseases. Acta Physiol Sin 2019; 71 (5): 769-782 (in Chinese with English abstract).