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鞘内激活MrgC受体在病理性疼痛和吗啡耐受中的作用

李幼萍^*, 江剑平

福建师范大学生命科学学院，福建省发育和神经生物学重点实验室，福州 350117

摘要

啮齿类动物的MrgC受体(Mas-related G-protein-coupled receptor subtype C)与人类Mas相关基因X受体1 (human Mas- related gene X receptor 1, hMrgX1)享有65%的同源序列和相似的表达模式以及结合谱，因此学者一般通过研究MrgC受体的功能来探索hMrgX1的作用。MrgC受体属于G蛋白耦联受体家族的一员，特异性地表达在背根神经节(dorsal root ganglion, DRG)和三叉神经节(trigeminal ganglion, TG)的小直径神经元上，与痛觉的传递过程密切相关。本文综述了鞘内激活MrgC受体在病理性疼痛和吗啡耐受中的镇痛作用。

关键词： 人类Mas相关基因X受体1; MrgC受体; 背根神经节; 脊髓背角; 病理性疼痛; 吗啡耐受

分类号：Q426

Involvement of intrathecal activation of MrgC receptor in pathological pain and morphine tolerance

LI You-Ping^*, JIANG Jian-Ping

College of Life Sciences, Fujian Normal University, Fujian Key Laboratory of Developmental and Neuro Biology, Fuzhou 350117, China

Abstract

Rodent MrgC receptor (Mas-related G-protein-coupled receptor subtype C) shares 65% sequence homology and similarities in terms of expression pattern and binding profile with human Mas-related gene X receptor 1 (hMrgX1). Therefore, researchers generally explore the role of hMrgX1 by studying the function of MrgC receptor. Murine MrgC receptor is uniquely expressed in small-diameter neurons of dorsal root ganglia (DRG) and trigeminal ganglia (TG), which is closely related to the transmission process of pain. This review summarizes the analgesic effects of intrathecal activation of MrgC receptors in pathological pain and morphine tolerance.

Key words: human Mas-related gene X receptor 1; Mas-related G-protein-coupled receptor subtype C; dorsal root ganglion; spinal dorsal horn; pathological pain; morphine tolerance

收稿日期：2018-12-09　　录用日期：2019-01-14

通讯作者：李幼萍　　E-mail:

DOI: 10.13294/j.aps.2019.0031

引用本文：

李幼萍, 江剑平. 鞘内激活MrgC受体在病理性疼痛和吗啡耐受中的作用[J]. 生理学报 2019; 71 (5): 741-748.

LI You-Ping, JIANG Jian-Ping. Involvement of intrathecal activation of MrgC receptor in pathological pain and morphine tolerance. Acta Physiol Sin 2019; 71 (5): 741-748 (in Chinese with English abstract).