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巨噬细胞极化及其在慢性阻塞性肺疾病中的作用

李尹¹, 鲁静¹, 张毅¹, 程晨¹, 刘自兵^2,*

¹安徽中医药大学研究生院，合肥 230012；²安徽中医药大学针灸推拿学院，合肥 230012

摘要

巨噬细胞具有高度可塑性，在炎症因子的诱导和多种信息分子的调控下可极化为经典活化巨噬细胞(M1)和替代活化巨噬细胞(M2)。慢性肺部炎症反应和肺实质损伤是慢性阻塞性肺疾病(chronic obstructive pulmonary disease, COPD)的主要病理表现。M1促进肺部炎症反应；M2抑制炎症反应，参与肺组织损伤与修复，并吞噬和清除病原微生物和凋亡细胞。靶向干预巨噬细胞极化方向有可能成为COPD治疗的新策略。

关键词： 巨噬细胞; 巨噬细胞极化; 慢性阻塞性肺疾病

分类号：R562.2; R563.3; Q471

Macrophages polarization and their role in chronic obstructive pulmonary disease

LI Yin¹, LU Jing¹, ZHANG Yi¹, CHENG Chen¹, LIU Zi-Bing^2,*

¹Graduate School, Anhui University of Chinese Medicine, Hefei 230012, China；²Acupuncture and Tuina College, Anhui University of Chinese Medicine, Hefei 230012, China

Abstract

Macrophages are highly plastic and can be polarized into classical activated macrophages (M1) and alternative activated macrophages (M2) under the induction of inflammatory factors and regulation of a variety of information molecules. Chronic pulmonary inflammation and pulmonary parenchyma injury are the main pathological manifestations of chronic obstructive pulmonary disease (COPD). M1 promotes pulmonary inflammation, whereas M2 inhibits inflammatory response, participates in lung tissue injury and repair, and swallows and removes pathogenic microorganisms and apoptotic cells. Target intervention in the polarization direction of macrophages may be a new strategy for COPD treatment.

Key words: Macrophages; macrophages polarization; chronic obstructive pulmonary disease

收稿日期：2018-12-17　　录用日期：2019-04-08

通讯作者：刘自兵　　E-mail: zibingliu@163.com

DOI: 10.13294/j.aps.2019.0055

引用本文：

李尹, 鲁静, 张毅, 程晨, 刘自兵. 巨噬细胞极化及其在慢性阻塞性肺疾病中的作用[J]. 生理学报 2019; 71 (4): 604-612.

LI Yin, LU Jing, ZHANG Yi, CHENG Chen, LIU Zi-Bing. Macrophages polarization and their role in chronic obstructive pulmonary disease. Acta Physiol Sin 2019; 71 (4): 604-612 (in Chinese with English abstract).