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前列腺素E₂受体EP4与脂肪生成及代谢

余敬伟^1,2, 彭军¹, 张晓燕³, 苏文¹, 管又飞^3,*

¹深圳大学医学院，深圳 518060；²广东药科大学基础学院，广州 510006；³大连医科大学医学科学研究院，大连 116044

摘要

脂肪是身体的储能器官，能量以脂滴的形式储存在脂肪细胞中，脂肪组织的功能稳态是机体维持正常代谢活动的基础。前列腺素E2 (prostaglandin E2, PGE2)是体内重要的脂质活性分子，广泛表达于机体组织中，参与血压、糖脂代谢、炎症等众多生理过程的调节。大量证据表明PGE2合成酶及其受体在白色脂肪组织中大量表达，提示PGE2参与脂肪代谢的调节。PGE2发挥生物学功能，需要通过其G蛋白耦联受体EP1~4介导，其中EP4受体亚型在脂肪生成及代谢中发挥了重要作用，EP4受体的激活可以抑制前脂肪细胞的分化，EP4受体的缺失促进脂质分解。本文将综述EP4受体与脂肪发生及代谢的关系，并提出EP4受体有可能成为肥胖及相关代谢疾病新的治疗靶点。

关键词： 前列腺素E2; EP4; 脂肪代谢

分类号：Q493.5

Role of prostaglandin E₂ receptor EP4 in the regulation of adipogenesis and adipose metabolism

YU Jing-Wei^1,2, PENG Jun¹, ZHANG Xiao-Yan³, SU Wen¹, GUAN You-Fei^3,*

¹Health Science Center, Shenzhen University, Shenzhen 518060, China；²School of Basic Courses, Guangdong Pharmaceutical University, Guangzhou 510006, China；³Advanced Institute of Medical Science, Dalian Medical University, Dalian 116044, China

Abstract

Adipose tissue is the energy storage organ of the body, and excess energy is stored in adipocytes in the form of lipid droplets. The homeostasis of adipose tissue is the basis for the body to maintain normal metabolic activity. Prostaglandin E2 (PGE2) is an important lipid mediator in the body. It is synthesized in almost all tissues and participates in the regulation of many physiological processes such as blood pressure, glucose and lipid metabolism, and inflammation. PGE2 is abundant in white adipose tissue, where it is involved in the regulation of fat metabolism. PGE2 plays its biological role through binding to four G protein coupled receptors (prostaglandin E2 receptors), including EP-1, -2, -3, and -4. The EP4 subtype has been proved to play an important role in adipogenesis and adipose metabolism: it could inhibit adipogenesis while it was activated, whereas its knockout could promote lipolysis. This review summarized the relationship between EP4 and adipose metabolism, hoping to identify new targets of drug development for metabolic disorders.

Key words: prostaglandin E2; EP4; adipose metabolism

收稿日期：2018-08-08　　录用日期：2018-12-13

通讯作者：管又飞　　E-mail: guanyf@dmu.edu.cn

DOI: 10.13294/j.aps.2019.0011

引用本文：

余敬伟, 彭军, 张晓燕, 苏文, 管又飞. 前列腺素E₂受体EP4与脂肪生成及代谢[J]. 生理学报 2019; 71 (3): 491-496.

YU Jing-Wei, PENG Jun, ZHANG Xiao-Yan, SU Wen, GUAN You-Fei. Role of prostaglandin E₂ receptor EP4 in the regulation of adipogenesis and adipose metabolism. Acta Physiol Sin 2019; 71 (3): 491-496 (in Chinese with English abstract).