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脂联素减轻糖尿病血管内皮损伤的保护机制

杜芸辉, 马新亮^*

首都医科大学附属北京安贞医院-北京市心肺血管疾病研究所，北京 100029

摘要

糖尿病合并心血管疾病的发病率和死亡率逐年上升，已成为威胁人类健康的首要公共卫生问题。而高糖/高脂所致内皮细胞急性功能障碍与慢性结构损伤是糖尿病心血管病的重要始动因素。脂联素是由脂肪细胞分泌的具有细胞保护作用的内源性蛋白，大量研究表明，脂联素对高糖所致的血管内皮损伤具有保护效应。本文就脂联素减轻糖尿病血管内皮急性功能障碍和慢性结构损伤的保护机制作一综述。

关键词： 脂联素; 血管内皮保护; 机制

分类号：R34

Mechanisms of adiponectin protection against diabetes-induced vascular endothelial injury 

DU Yun-Hui, MA Xin-Liang^*

Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China

Abstract

The incidence and mortality rates of diabetes with cardiovascular complications are continually rising, and diabetic cardiovascular disease is becoming a major public health issue that threatens human health. Acute endothelial dysfunction and chronic cellular damage caused by diabetes are important risk factors for diabetic cardiovascular disease and related mortality. Adiponectin is an adipocyte-derived molecule with significant cytoprotective effects, including the protection against diabetes-induced vascular endothelial injury. Here we review the mechanisms of adiponectin protective effects on acute vascular endothelial dysfunction and chronic structural damage induced by diabetes.

Key words: adiponectin; vascular endothelial protection; mechanism

收稿日期：2018-08-21　　录用日期：2018-10-16

通讯作者：马新亮　　E-mail: xinma2006@gmail.com

DOI: 10.13294/j.aps.2019.0041

引用本文：

杜芸辉, 马新亮. 脂联素减轻糖尿病血管内皮损伤的保护机制[J]. 生理学报 2019; 71 (3): 485-490.

DU Yun-Hui, MA Xin-Liang. Mechanisms of adiponectin protection against diabetes-induced vascular endothelial injury . Acta Physiol Sin 2019; 71 (3): 485-490 (in Chinese with English abstract).