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内源性神经干细胞促进缺血性脑卒中后神经修复的研究进展

房昌运¹, 吴旭升¹, 张航¹, 谷燕苓¹, 王士兵¹, 任慧文¹, 陈珂¹, 张慧², 程葆华², 高洋^2,*

¹济宁医学院临床学院，济宁 272067；²济宁医学院基础医学院，济宁 272067

摘要

神经干细胞自1992年被发现以来，已成为治疗神经系统各类疾病的新希望。缺血性脑卒中因其高发病率、高致死率和高致残率而倍受关注。损伤后的大脑自我修复能力有限，因此只能适度改善神经功能，而加快神经再生才能从根本上阻止神经系统疾病的发生和发展。值得关注的是，部分患者在发病数月后可表现出脑修复能力，提示可能存在内源性的神经修复。本文对近年来内源性神经干细胞在缺血性脑卒中后的神经再生及相关调控因素的研究进展进行综述，为促进缺血性脑卒中后的神经修复提供新的治疗思路。

关键词： 缺血性脑卒中; 内源性神经干细胞; 神经再生; 研究进展

分类号：R338.2;R743.3

Research advances in endogenous neural stem cells promoting neural repair after ischemic stroke

FANG Chang-Yun¹, WU Xu-Sheng¹, ZHANG Hang¹, GU Yan-Ling¹, WANG Shi-Bing¹, REN Hui-Wen¹, CHEN Ke¹, ZHANG Hui², CHENG Bao-Hua², GAO Yang^2,*

¹School of Clinical Medicine, Jining Medical University, Jining 272067, China；²College of Basic Medical Sciences, Jining Medical University, Jining 272067, China

Abstract

Neural stem cell therapy, as a new therapeutic method for neural diseases, has aroused a wide concern for over 20 years since neural stem cells were first found in 1992. Ischemic stroke is highly concerned because of its high incidence, mortality and disability rates. Because the brain has a limited ability to repair itself, to improve neural function and promote neural regeneration may help to prevent occurrence and development of neurological diseases. It is noteworthy that some stroke patients showed an ability to repair brain several months after the stroke happened, suggesting an existence of endogenous nerve repair in these patients. The research advances in functions of endogenous neural stem cells in neural regeneration and the related regulators after ischemic stroke are summarized in this review to provide new views of the mechanism of neural functional recovery after ischemic stroke.

Key words: ischemic stroke; endogenous neural stem cells; neural regeneration; research progress

收稿日期：2018-08-11　　录用日期：2018-10-08

通讯作者：高洋　　E-mail: gyjnmc2017@yeah.net

DOI: 10.13294/j.aps.2019.0035

引用本文：

房昌运, 吴旭升, 张航, 谷燕苓, 王士兵, 任慧文, 陈珂, 张慧, 程葆华, 高洋. 内源性神经干细胞促进缺血性脑卒中后神经修复的研究进展[J]. 生理学报 2019; 71 (3): 454-462.

FANG Chang-Yun, WU Xu-Sheng, ZHANG Hang, GU Yan-Ling, WANG Shi-Bing, REN Hui-Wen, CHEN Ke, ZHANG Hui, CHENG Bao-Hua, GAO Yang. Research advances in endogenous neural stem cells promoting neural repair after ischemic stroke. Acta Physiol Sin 2019; 71 (3): 454-462 (in Chinese with English abstract).