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癌性疼痛，肿瘤患者的严重威胁

欧阳雪岩¹, 杨超², 朱朕³, 李静¹, 孙运恒¹, 丁罡⁴, 吉永华³, 姜峰^2,*

¹上海交通大学医学院附属新华医院肿瘤科，上海 200092；²上海交通大学医学院附属新华医院崇明分院科研科，上海 202150；³上海市崇明新华癌痛转化研究所，上海 202150；⁴上海国际医学中心肿瘤科，上海 201318

摘要

癌性疼痛严重困扰着肿瘤患者及其家庭。有临床研究表明，疼痛或可成为促进肿瘤进程的危险因素。神经系统与肿瘤间存在诸多共享调控分子和途径，如多种神经递质、神经源性细胞因子等，为疼痛影响肿瘤进程提供了必要的基础条件。本文分别从中枢神经系统对内分泌和免疫的系统性调控，及外周神经系统对肿瘤细胞的局部性影响等方面，综述了疼痛加剧肿瘤的可能机制，以期揭示癌性疼痛的临床危害及抗痛在肿瘤诊疗中的重要性。

关键词： 疼痛; 肿瘤; 神经-内分泌-免疫调控

分类号：R730.6

Cancer pain, a serious threat to patients

OUYANG Xue-Yan¹, YANG Chao², ZHU Zhen³, LI Jing¹, SUN Yun-Heng¹, DING Gang⁴, JI Yong-Hua³, JIANG Feng^2,*

¹Oncology Department, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China；²Scientific Research Management Department, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Chongming Branch, Shanghai 202150, China；³Xinhua Translational Institute for Cancer Pain, Shanghai 202150, China；⁴Oncology Department, Shanghai International Medical Center, Shanghai 201318, China

Abstract

A large number of cancer patients suffer from pain. Growing evidence suggested that pain might be a serious risk factor for cancer patients. The shared modulators and modulation pathways between neural system and tumor cells, such as various neurotransmitters and neurogenic cytokines, provide essential basis for the effect of pain on tumor. In this article, we reviewed some possible mechanism of this process from two aspects: the systematic regulation of central nervous system on endocrine and immunity, and the regional regulation of peripheral nerves on tumor cells. The aim of this review is to provide more innovative knowledge about pain and cancer and to emphasize the importance of anti-pain in the therapy of cancer.

Key words: Pain; tumor; neuro-endocrine-immune regulation

收稿日期：2018-05-04　　录用日期：2018-12-14

通讯作者：姜峰　　E-mail: jf365321@163.com

DOI: 10.13294/j.aps.2019.0022

引用本文：

欧阳雪岩, 杨超, 朱朕, 李静, 孙运恒, 丁罡, 吉永华, 姜峰. 癌性疼痛，肿瘤患者的严重威胁[J]. 生理学报 2019; 71 (2): 343-349.

OUYANG Xue-Yan, YANG Chao, ZHU Zhen, LI Jing, SUN Yun-Heng, DING Gang, JI Yong-Hua, JIANG Feng. Cancer pain, a serious threat to patients. Acta Physiol Sin 2019; 71 (2): 343-349 (in Chinese with English abstract).