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AMPK激活剂抗炎保护效应研究进展

彭先稳¹, 周虹宏¹, 代洁², 张力^1,3,*

¹重庆医科大学病理生理学教研室，重庆 400016；²重庆文理学院校医院，重庆402160；³重庆医科大学干细胞与组织工程研究室，重庆 400016

摘要

腺苷酸活化蛋白激酶(AMP-activated protein kinase, AMPK)是细胞能量调节的关键激酶，近期研究表明AMPK也在炎症这一高耗能分子反应中发挥重要调控作用。目前常用的AMPK激活剂有5-氨基咪唑-4-甲酰胺核苷酸(5-aminoimidazole- 4-carboxamide ribonucleotide, AICAR)和A-769662，此外二甲双胍及脂联素发挥生物活性也与激活AMPK密切相关。大量研究表明，这些激活剂可在急性肺损伤、哮喘、结肠s炎、肝炎、动脉粥样硬化等多种炎症相关性疾病动物模型中发挥有效的保护作用。因而，AMPK激活剂在炎症相关性疾病的防治中具有广阔的研发和应用前景。

关键词： 腺苷酸活化蛋白激酶; AICAR; A-769662; 二甲双胍; 脂联素

分类号：R332; R363.2; R329.2

Advances on the anti-inflammatory and protective effect of AMPK activators

PENG Xian-Wen¹, ZHOU Hong-Hong¹, DAI Jie², ZHANG Li^1,3,*

¹Department of Pathophysiology, Chongqing Medical University, Chongqing 400016, China；²Hospital of Chongqing University of Arts and Sciences, Chongqing 402160, China；³Laboratory of Stem Cell and Tissue Engineering, Chongqing Medical University, Chongqing 400016, China

Abstract

AMP-activated protein kinase (AMPK) is a key enzyme in the regulation of cellular energy homeostasis. Recent studies demonstrated that AMPK also plays an important role in the modulation of inflammation, an energy-intensive molecular response. The commonly used AMPK activators include 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) and A-769662. In addition, the biological activities of metformin and adiponectin are closely related to activation of AMPK. Numerous studies have shown that these AMPK activators play an effectively protective role in animal models of acute lung injury, asthma, colitis, hepatitis, atherosclerosis and other inflammatory diseases. Therefore, AMPK activators may have promising potential for the prevention and treatment of inflammation related diseases.

Key words: AMP-activated protein kinase; AICAR; A-769662; metformin; adiponectin

收稿日期：2018-04-21　　录用日期：2018-09-12

通讯作者：张力　　E-mail: zhangli@cqmu.edu.cn

DOI: 10.13294/j.aps.2018.0094

引用本文：

彭先稳, 周虹宏, 代洁, 张力. AMPK激活剂抗炎保护效应研究进展[J]. 生理学报 2019; 71 (2): 319-326.

PENG Xian-Wen, ZHOU Hong-Hong, DAI Jie, ZHANG Li. Advances on the anti-inflammatory and protective effect of AMPK activators. Acta Physiol Sin 2019; 71 (2): 319-326 (in Chinese with English abstract).