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高血压病血管重塑的分子机制及中医药干预

张婵娟^1,2, 石雅宁^1,2, 廖端芳², 杜可¹, 覃丽^1,2,*

¹湖南中医药大学药学院药理教研室，长沙 410208；²湖南中医药大学干细胞中药调控与应用实验室，长沙 410208

摘要

血管重塑是高血压病的一种显著性病理特征，在发展过程中受到复杂的调控网络调控。血管重塑早期是一种适应性的过程，但最终变为适应不良和失代偿，损害心、脑、肾等重要靶器官，引发高血压并发症。本文就目前报道的血管重塑在高血压病及并发症病程进展中的作用和机制研究进展作一综述，并阐述了中医药干预血管重塑的基础及临床研究依据。深入阐明高血压病血管重塑的分子机制、治疗靶点及活性物质筛选将有助于提供有效的血管保护方法。

关键词： 血管重塑; 高血压; 中医药; 分子机制

分类号：R329.2

Molecular mechanism of vascular remodeling in hypertension and Chinese medicine intervention

ZHANG Chan-Juan^1,2, SHI Ya-Ning^1,2, LIAO Duan-Fang², DU Ke¹, QIN Li^1,2,*

¹Department of Pharmacology, School of Pharmacy, Changsha 410208, China；²Division of Stem Cell Regulation and Application, Hunan University of Chinese Medicine, Changsha 410208, China

Abstract

Vascular remodeling is a significant pathological characteristic of hypertension, which is regulated by complex regulatory networks. The vascular remodeling may be adaptive initially, however it becomes maladaptive and decompensation eventually and further compromises target organ function, leading to hypertensive cardiovascular complications. This review focuses on the role and mechanisms of vascular remodeling in the pathogenesis and progression of hypertension and its complications. Moreover, the strategies of syndrome differentiation of traditional Chinese medicine application provide clinical and theoretical evidences for hypertensive vascular remodeling therapy. A better understanding of underlying signaling pathways, therapeutic targets in vascular remodeling, as well as screening of active ingredients from traditional Chinese medicine may be able to provide some effective approaches for vascular protection in hypertensive diseases.

Key words: vascular remodeling; hypertension; traditional Chinese medicine; molecular mechanism

收稿日期：2018-06-28　　录用日期：2018-12-23

通讯作者：覃丽　　E-mail: lqin1011@126.com

DOI: 10.13294/j.aps.2019.0014

引用本文：

张婵娟, 石雅宁, 廖端芳, 杜可, 覃丽. 高血压病血管重塑的分子机制及中医药干预[J]. 生理学报 2019; 71 (2): 235-247.

ZHANG Chan-Juan, SHI Ya-Ning, LIAO Duan-Fang, DU Ke, QIN Li. Molecular mechanism of vascular remodeling in hypertension and Chinese medicine intervention. Acta Physiol Sin 2019; 71 (2): 235-247 (in Chinese with English abstract).