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硫酸吲哚酚在终末期肾病心血管并发症中的研究进展

郭楚楚, 夏薇薇, 张爱华^*

南京医科大学附属儿童医院肾脏内科，南京 210008

摘要

心血管疾病是慢性肾脏病患者最常见的并发症之一，也是慢性肾脏病患者死亡的主要原因。尿毒症毒素是肾功能不全时导致心血管疾病发生的重要因素。在慢性肾脏病患者中，以硫酸吲哚酚为代表的蛋白结合性尿毒症毒素，是一类很难通过常规透析方式清除的物质，且毒性极大。近年来，已有研究证实慢性肾脏病诱导心血管疾病的发生与硫酸吲哚酚的蓄积密切相关。硫酸吲哚酚可通过诱导氧化应激导致内皮损伤，平滑肌细胞增殖和迁移，促进动脉粥样硬化发生，从而影响全身多个系统。本文就尿毒症毒素硫酸吲哚酚在终末期肾病心血管并发症中的研究进展作一综述。

关键词： 慢性肾脏病; 尿毒症毒素; 硫酸吲哚酚; 心血管疾病

分类号：R334+.1; R692

Research progress of the uremic toxin indoxyl sulfate in cardiovascular complication of end-stage renal diseases

GUO Chu-Chu, XIA Wei-Wei, ZHANG Ai-Hua^*

Department of Nephrology, Children’s Hospital of Nanjing Medical University, Nanjing 210008, China

Abstract

Cardiovascular disease is one of the most common complications and the main cause of death in patients with chronic kidney disease. Uremic toxins are the primary cause of cardiovascular disease in renal insufficiency. In patients with chronic kidney disease, the protein-bound uremic toxins represented by indoxyl sulfate are difficult to be removed by conventional dialysis and are extremely toxic. In recent years, studies have confirmed that the occurrence of cardiovascular disease induced by chronic kidney disease is closely related to the accumulation of indoxyl sulfate. Indoxyl sulfate can induce oxidative stress to cause endothelial injury, smooth muscle cell proliferation and migration, and promote the occurrence of atherosclerosis, thereby affecting multiple systems throughout the body. This article reviews the research progress of uremic toxin indoxyl sulfate in end-stage renal diseases associated cardiovascular diseases.

Key words: chronic kidney disease; uremic toxin; indoxyl sulfate; cardiovascular disease

收稿日期：2018-11-11　　录用日期：2018-11-28

通讯作者：张爱华　　E-mail: zhaihua@njmu.edu.cn

DOI: 10.13294/j.aps.2018.0090

引用本文：

郭楚楚, 夏薇薇, 张爱华. 硫酸吲哚酚在终末期肾病心血管并发症中的研究进展[J]. 生理学报 2018; 70 (6): 657-662.

GUO Chu-Chu, XIA Wei-Wei, ZHANG Ai-Hua. Research progress of the uremic toxin indoxyl sulfate in cardiovascular complication of end-stage renal diseases. Acta Physiol Sin 2018; 70 (6): 657-662 (in Chinese with English abstract).