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慢性肾脏病尿液生物标志物研究进展：聚焦RNA转录标志物

吕林莉, 刘必成^*

东南大学肾脏病研究所/东南大学附属中大医院肾脏科，南京 210009

摘要

慢性肾脏病(chronic kidney disease, CKD)已经越来越成为世界范围内的主要疾病负担之一，然而，目前仍缺乏早期诊断及动态监测其发生和发展的生物标志物。因此，在未来的精准医疗时代，寻找敏感、无创诊断标志物已经成为CKD诊疗所面临的重要挑战。本文将从尿液的沉渣、上清、细胞外囊泡三个方面，聚焦基因转录标志物(miRNA, mRNA)，论述CKD尿液生物标志物的研究进展及尿液基因转录标志物研究所面临的挑战和未来可能的研究方向。

关键词： 尿液; 生物标志物; 慢性肾脏病; 细胞外囊泡; 基因转录

分类号：R334; R692

Urinary biomarkers for chronic kidney disease: a focus on gene transcript

LYU Lin-Li, LIU Bi-Cheng^*

Institute of Nephrology, Zhongda Hospital, Southeast University, Nanjing 210009, China

Abstract

Chronic kidney disease (CKD) is becoming an alarming health burden worldwide, however, there is still lack of early     biomarkers and effective treatment options. Thus, in the upcoming era of precision medicine, searching for the sensitive, non-invasive biomarkers has been the cornerstone and major challenge in the management of CKD. Urine contains rich biological information which could be an ideal source for non-invasive biomarkers of CKD. This review will discuss the recent advances in biomarker study from urine sediment, urine supernatant and urinary extracellular vesicles with special interest in gene transcript (miRNA, mRNA) biomarkers. Besides, the challenges and future directions for urinary gene transcript biomarker study will be discussed.  

Key words: urine; biomarkers; chronic kidney disease; extracellular vesicle; gene transcript

收稿日期：2018-06-05　　录用日期：2018-10-11

通讯作者：刘必成　　E-mail: liubc64@163.com

DOI: 10.13294/j.aps.2018.0070

引用本文：

吕林莉, 刘必成. 慢性肾脏病尿液生物标志物研究进展：聚焦RNA转录标志物[J]. 生理学报 2018; 70 (6): 644-648.

LYU Lin-Li, LIU Bi-Cheng. Urinary biomarkers for chronic kidney disease: a focus on gene transcript. Acta Physiol Sin 2018; 70 (6): 644-648 (in Chinese with English abstract).