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氢气对心脑血管疾病的防治作用及机制的研究进展

薛俊莉, 宋国华, 秦树存^*

山东省高校动脉粥样硬化重点实验室，泰山医学院动脉粥样硬化研究所，泰山氢生物医学研究院，泰安 271000

摘要

以往，氢气(H₂)被认为是生理上的惰性气体。但是，近年来的研究表明，H₂具有抗氧化、抗炎、抗凋亡等作用，在多种疾病模型中有显著的治疗效果，且在多项临床试验中也得到了较好的验证。心脑血管疾病是全世界致死率最高的疾病，严重威胁人类生命健康。本文就H₂在心脑血管疾病中的生物医学效应及其可能的分子机制进行综述，以期全面介绍H₂在该类疾病中的生物医学效应的最新研究进展，并为某些心脑血管疾病的临床治疗提供新思路。

关键词： 氢气; 心脑血管疾病; 生物医学效应; 分子机制

分类号：R363

Research advances on preventive and therapeutic effects of hydrogen on cardiovascular and cerebrovascular diseases and underlying mechanisms

XUE Jun-Li, SONG Guo-Hua, QIN Shu-Cun^*

y Laboratory of Atherosclerosis in Colleges and Universities of Shandong Province, Institute of Atherosclerosis of Taishan Medical University, Taishan Institute for Hydrogen Biomedical Research, Taian 271000, China

Abstract

For a long time, hydrogen (H₂) has been considered as a physiological inert gas. However, recent studies have demonstrated that molecular H₂ exerts significant therapeutic effects on various disease models due to its antioxidative, anti-inflammatory and anti-apoptotic capabilities, which have also been well confirmed in many clinical trials. Cardiovascular and cerebrovascular diseases (CCVDs) are the leading cause of death in the world, constituting a serious threat to human life and public health. In this paper, we reviewed the latest research progress of the biomedical effects of H₂ in CCVDs and its possible molecular mechanisms, in the hope of providing new clues for the treatment of some CCVDs.

Key words: hydrogen; cardiovascular and cerebrovascular diseases; biomedical effects; molecular mechanism

收稿日期：2018-01-19　　录用日期：2018-09-13

通讯作者：秦树存　　E-mail: shucunqin@hotmail.com

DOI: 10.13294/j.aps.2018.0060

引用本文：

薛俊莉, 宋国华, 秦树存. 氢气对心脑血管疾病的防治作用及机制的研究进展[J]. 生理学报 2018; 70 (5): 557-564.

XUE Jun-Li, SONG Guo-Hua, QIN Shu-Cun. Research advances on preventive and therapeutic effects of hydrogen on cardiovascular and cerebrovascular diseases and underlying mechanisms. Acta Physiol Sin 2018; 70 (5): 557-564 (in Chinese with English abstract).