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中枢胆碱能系统投射支配鸣禽鸣唱控制系统并调控鸣唱行为

王青沁¹, 王松华¹, 姚丽华², 孟玮^1,*

¹江西科技师范大学有机功能分子研究所，南昌 330013；²江西科技师范大学生命科学学院，南昌 330013

摘要

鸣禽因其独特的习得性鸣唱行为，成为了研究运动学习的理想模型。现已证实，鸣禽的鸣唱行为受前脑内的鸣唱控制系统直接调控。有证据显示，鸣唱控制系统内有胆碱能递质及其受体分布，其中发声运动核团接受来自基底前脑中枢胆碱能系统的胆碱能神经支配，其可通过胆碱能递质影响发声运动核团的神经活动，进而影响鸣唱行为。在哺乳动物中的研究证实，中枢胆碱能系统参与了对运动行为和运动学习神经过程的调控。了解中枢胆碱能系统对鸣禽鸣唱行为的调控作用，有助于更好地理解鸣禽鸣唱运动控制和鸣唱学习记忆的神经机制，并可从比较生理学的角度，为研究其它动物感觉运动和学习记忆的神经过程，乃至人类语言产生的神经过程提供重要参考。本文对迄今国内外在胆碱能递质对鸣禽发声运动核团作用受体的选择性及其对神经元活动影响的研究进展进行了综述，为揭示中枢胆碱能系统调控鸣禽鸣唱行为的神经机理提供有价值的线索。

关键词： 中枢胆碱能系统; 鸣禽; 鸣唱控制系统; 鸣唱行为; 感觉运动; 学习记忆

分类号：Q424

Central cholinergic system innervates song control system of songbirds and regulates song behavior

WANG Qing-Qin¹, WANG Song-Hua¹, YAO Li-Hua², Meng Wei^1,*

¹Institute of Organic Functional Molecules, Jiangxi Science and Technology Normal University, Nanchang 330013, China；²School of Life Science, Jiangxi Science and Technology Normal University, Nanchang 330013, China

Abstract

Songbird has become an ideal model for studying motor learning due to its unique learned song behavior. It has been proved that song behavior is directly regulated by song control system in the forebrain of songbirds. There are lines of evidence to show that cholinergic transmitters and their receptors are distributed in song control system, and vocal control nuclei in song control system are innervated by cholinergic nerves from the central cholinergic system in basal forebrain, which can affect activities of vocal control nuclei through cholinergic transmitters, and then affect song behavior. Studies in mammals have confirmed that the central cholinergic system is involved in the regulation of motor behavior and neural process of motor learning. Elucidation of regulation of songbirds’ song behavior by central cholinergic system would shed light on the neural mechanism of song motor control and song learning and memory in songbirds, and provide theoretical insights for researches on other animals’ sensorimotor processes and human language learning. This review summarized recent progresses, including the research work of our laboratory, in the studies on the selectivity of cholinergic transmitters to their receptors and their effects on neuronal activities in vocal control nuclei of songbirds and provided valuable clues for revealing the regulation mechanism of central cholinergic system on songbirds’ song behavior.

Key words: central cholinergic system; songbird; song control system; song behavior; sensorimotor processes; learning and memory

收稿日期：2018-03-05　　录用日期：2018-06-26

通讯作者：孟玮　　E-mail: meng7883@163.com

DOI: 10.13294/j.aps.2018.0047

引用本文：

王青沁, 王松华, 姚丽华, 孟玮. 中枢胆碱能系统投射支配鸣禽鸣唱控制系统并调控鸣唱行为[J]. 生理学报 2018; 70 (5): 539-547.

WANG Qing-Qin, WANG Song-Hua, YAO Li-Hua, Meng Wei. Central cholinergic system innervates song control system of songbirds and regulates song behavior. Acta Physiol Sin 2018; 70 (5): 539-547 (in Chinese with English abstract).