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整合素β4研究进展

迟寅秀¹, 向阳², 秦晓群^2,*

¹陇东学院，庆阳 745000；²中南大学基础医学院生理学系，长沙 410013

摘要

整合素又名整联蛋白，是一种介导细胞与其外环境如细胞外基质之间连接的跨膜受体。整合素β4因其特殊的结构，发挥着诸多功能：与整合素α6亚单位组成α6β4，参与构成半桥粒；介导细胞与细胞外基质相互作用、细胞与细胞间相互作用；介导细胞的增殖与存活，迁移和侵袭；通过激活多条信号通路参与各种疾病进程。本文将对整合素β4的结构组成、生理功能及其在呼吸系统、肿瘤、神经系统等相关疾病中的作用进行综述。

关键词： 整合素β4; 半桥粒; 细胞迁移

分类号：R33

The research progress of integrin β4 

CHI Yin-Xiu¹, Xiang Yang², QIN Xiao-Qun^2,*

¹Longdong College, Qingyang 745000, China；²Department of Physiology, Xiangya School of Medicine, Central South University, Changsha 410013, China

Abstract

Integrin is a transmembrane receptor that mediates the connection between cells and their external environment, such as extracellular matrix (ECM). Integrin β4 (ITGβ4) plays a number of functions due to its special structures: forms α6β4 with ITGα6 subunit and participates in the formation of hemidesmosomes; mediates cell-to-cell matrix interaction and cell-to-cell interaction, cell proliferation and survival, as well as migration and invasion. Also, ITGβ4 participates in various disease processes by activating multiple signaling pathways. In this paper, the structure, physiological function and function of ITGβ4 in respiratory system, tumor, nervous system and other related diseases will be reviewed.

Key words: integrin β4; hemidesmosome; cell migration

收稿日期：2018-02-25　　录用日期：2018-09-13

通讯作者：秦晓群　　E-mail: qinxiaoqun@csu.edu.cn

DOI: 10.13294/j.aps.2018.0059

引用本文：

迟寅秀, 向阳, 秦晓群. 整合素β4研究进展[J]. 生理学报 2018; 70 (5): 504-510.

CHI Yin-Xiu, Xiang Yang, QIN Xiao-Qun. The research progress of integrin β4 . Acta Physiol Sin 2018; 70 (5): 504-510 (in Chinese with English abstract).