ISSN 0371-0874, CN 31-1352/Q



迟寅秀1, 向阳2, 秦晓群2,*

1陇东学院,庆阳 745000;2中南大学基础医学院生理学系,长沙 410013



关键词: 整合素β4; 半桥粒; 细胞迁移


The research progress of integrin β4 

CHI Yin-Xiu1, Xiang Yang2, QIN Xiao-Qun2,*

1Longdong College, Qingyang 745000, China;2Department of Physiology, Xiangya School of Medicine, Central South University, Changsha 410013, China


Integrin is a transmembrane receptor that mediates the connection between cells and their external environment, such as extracellular matrix (ECM). Integrin β4 (ITGβ4) plays a number of functions due to its special structures: forms α6β4 with ITGα6 subunit and participates in the formation of hemidesmosomes; mediates cell-to-cell matrix interaction and cell-to-cell interaction, cell proliferation and survival, as well as migration and invasion. Also, ITGβ4 participates in various disease processes by activating multiple signaling pathways. In this paper, the structure, physiological function and function of ITGβ4 in respiratory system, tumor, nervous system and other related diseases will be reviewed.

Key words: integrin β4; hemidesmosome; cell migration

收稿日期:2018-02-25  录用日期:2018-09-13

通讯作者:秦晓群  E-mail:

DOI: 10.13294/j.aps.2018.0059


迟寅秀, 向阳, 秦晓群. 整合素β4研究进展[J]. 生理学报 2018; 70 (5): 504-510.

CHI Yin-Xiu, Xiang Yang, QIN Xiao-Qun. The research progress of integrin β4 . Acta Physiol Sin 2018; 70 (5): 504-510 (in Chinese with English abstract).