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肝X受体与炎症相关疾病关系的研究进展

高碧聪¹, 陈泉², 孙婷¹, 王德明¹, 肖继^1,*

¹南华大学附属第二医院麻醉科，衡阳 421001；²长沙市第八医院麻醉科，长沙 410100

摘要

肝X受体(liver X receptors, LXRs)属核受体超家族成员，它活化后具有多种生物学功能，不仅可调控胆固醇、脂肪酸及葡萄糖等物质的代谢，而且在免疫炎症反应中发挥重要作用。众多研究表明，LXRs在炎症相关疾病的发生及发展过程中扮演重要角色，它可抑制神经系统、呼吸系统及心血管系统等全身多个系统炎症相关疾病的炎症反应。本文从LXRs的结构、功能及抗炎机制等方面，将近年来LXRs与炎症相关疾病关系的研究进展作一综述，为炎症相关疾病的治疗提供新思路。

关键词： 肝X受体; 炎症相关疾病; 抗炎机制

分类号：R363

Research progress of the relationship between liver X receptor and inflammatory- related diseases

GAO Bi-Cong¹, CHEN Quan², SUN Ting¹, WANG De-Ming¹, XIAO Ji^1,*

¹Department of Anesthesiology, The Second Hospital Affiliated to University of South China, Hengyang 421001, China；²Department of Anesthesiology, The Eighth Hospital of Changsha, Changsha 410100, China

Abstract

The liver X receptors (LXRs) are members of the nuclear receptor superfamily. The activated LXRs have a variety of biological functions, for instance they can not only regulate the metabolism of cholesterol, fatty acids and glucose, but also play an important role in immune inflammatory response. Massive studies have shown that LXRs are involved in the occurrence and progress of inflammatory-related diseases, and can inhibit the inflammation of some inflammatory-related diseases in the nervous system, the respiratory system, and the cardiovascular system. In this review, we summarized the recent progress regarding LXRs in inflammatory-related diseases, including the structure, function and anti-inflammatory mechanism of LXRs, in order to provide new methods for preventing and treating inflammatory-related diseases.

Key words: liver X receptors; inflammatory-related diseases; anti-inflammatory mechanism

收稿日期：2017-09-03　　录用日期：2017-12-05

通讯作者：肖继　　E-mail: 253477652@qq.com

DOI: 10.13294/j.aps.2018.0012

引用本文：

高碧聪, 陈泉, 孙婷, 王德明, 肖继. 肝X受体与炎症相关疾病关系的研究进展[J]. 生理学报 2018; 70 (3): 335-341.

GAO Bi-Cong, CHEN Quan, SUN Ting, WANG De-Ming, XIAO Ji. Research progress of the relationship between liver X receptor and inflammatory- related diseases. Acta Physiol Sin 2018; 70 (3): 335-341 (in Chinese with English abstract).