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腺苷酸活化蛋白激酶发挥抗炎作用的分子机制

刘明月¹, 张洺嘉¹, 谢明杰^1,2,*

¹辽宁师范大学生命科学学院，大连 116081；²辽宁省生物技术与分子药物研发重点实验室，大连 116081

摘要

腺苷酸活化蛋白激酶(AMP-activated protein kinase, AMPK)是一种进化保守的丝氨酸/苏氨酸蛋白激酶，被称为“细胞能量调节器”，是维持细胞和机体能量平衡的关键分子。近年来的研究显示，AMPK与炎症反应密切相关，其抗炎机制主要是通过激活SIRT1、PGC-1α、p53、FoxO3a和p300等途径，下调NF-κB、AP-1等多种炎性相关蛋白的活性来发挥作用。本文通过对AMPK发挥抗炎作用的分子机制进行综述，为以AMPK为靶点治疗炎症及相关疾病提供参考。

关键词： 腺苷酸活化蛋白激酶; 抗炎机制; 核因子-κB; AP-1

分类号：R364.5

Molecular mechanisms of anti-inflammatory action of AMPK

LIU Ming-Yue¹, ZHANG Ming-Jia¹, XIE Ming-Jie^1,2,*

¹College of Life Sciences, Liaoning Normal University, Dalian 116081, China；²Key Laboratory of Biotechnology and Drug Discovery of Liaoning Province, Dalian 116081, China

Abstract

 AMP-activated protein kinase (AMPK), an evolutionarily conserved serine/threonine protein kinase, is known as the “cellular energy regulator” and a key molecule to maintain the energy balance of cells and organism. Recent studies have shown that AMPK exerts anti-inflammatory effects mainly through activating SIRT1, PGC-1α, p53, FoxO3a and p300, and down-regulating the activity of various inflammatory related proteins such as NF-κB and AP-1. This article reviews the molecular mechanisms of the anti- inflammatory effects of AMPK, and provides some clues for the development of AMPK-targeted therapeutics to treat inflammation and related diseases.

Key words: AMP-activated protein kinase; anti-inflammatory mechanism; NF-κB; AP-1

收稿日期：2017-11-15　　录用日期：2018-01-05

通讯作者：谢明杰　　E-mail: xmj1222@sina.com

DOI: 10.13294/j.aps.2018.0020

引用本文：

刘明月, 张洺嘉, 谢明杰. 腺苷酸活化蛋白激酶发挥抗炎作用的分子机制[J]. 生理学报 2018; 70 (3): 329-334.

LIU Ming-Yue, ZHANG Ming-Jia, XIE Ming-Jie. Molecular mechanisms of anti-inflammatory action of AMPK. Acta Physiol Sin 2018; 70 (3): 329-334 (in Chinese with English abstract).