过刊浏览

组蛋白去乙酰化酶6抑制剂治疗缺血性脑卒中的研究进展

张琛琛, 卢芳, 梁嘉强, 周艳芳^*

广东医科大学病理生理学教研室，东莞 523808

摘要

组蛋白乙酰化酶(histone acetyltransferases, HATs)和组蛋白去乙酰化酶(histone deacetylases, HDACs)主导的蛋白质乙酰化修饰在神经系统的发育、成熟中具有重要地位。HDAC6属于II类HDACs，能够调节神经细胞的存活、分化和成熟，参与脑认知和情绪调控，在神经系统发育中具有重要作用，并且参与脑缺血损伤的多个病理环节。本文总结了近年来国内外最新研究成果，阐述了HDAC6抑制剂通过降低细胞兴奋性毒性、减轻氧化应激损伤、抑制炎症介质释放、抑制神经细胞凋亡以及促进神经再生和血管新生等多种方式对缺血性脑卒中发挥有效的神经保护作用。

关键词： 组蛋白去乙酰化酶6; 抑制剂; 缺血性脑卒中

分类号：R34;R362;R743.3

Research progress of histone deacetylase 6 inhibitors in the therapy of ischemic stroke

ZHANG Chen-Chen, LU Fang, LIANG Jia-Qiang, ZHOU Yan-Fang^*

Department of Pathophysiology, Guangdong Medical University, Dongguan 523808, China

Abstract

The protein acetylation by histone acetyltransferases (HATs) and histone deacetylases (HDACs) plays a significant role in the development and maturation of the nervous system. HDAC6, belonging to class II HDACs, by regulating the survival, differentiation and maturation of neural cells, plays an important role in the development of the nervous system and participates in multiple pathological processes of cerebral ischemic injury. In addition, HDAC6 participates in the regulation of cognition and emotion of the brain. This article summarized the latest research results in recent years and expounded that HDAC6 inhibitors could produce a positive and effective neuroprotective effect on ischemic stroke by reducing the neuronal damage induced by excitotoxicity and oxidative stress, depressing the release of inflammatory mediators, inhibiting the apoptosis of neurons and promoting the growth of nerve and blood vessel.

Key words: histone deacetylase 6; inhibitor; ischemic stroke

收稿日期：2017-11-10　　录用日期：2018-02-06

通讯作者：周艳芳　　E-mail: fangfang772003@163.com

DOI: 10.13294/j.aps.2018.0023

引用本文：

张琛琛, 卢芳, 梁嘉强, 周艳芳. 组蛋白去乙酰化酶6抑制剂治疗缺血性脑卒中的研究进展[J]. 生理学报 2018; 70 (3): 301-309.

ZHANG Chen-Chen, LU Fang, LIANG Jia-Qiang, ZHOU Yan-Fang. Research progress of histone deacetylase 6 inhibitors in the therapy of ischemic stroke. Acta Physiol Sin 2018; 70 (3): 301-309 (in Chinese with English abstract).