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血管外膜在低氧性血管重塑中的作用

于富洋, 杨胜昌, 吉恩生^*

河北中医学院基础医学院生理教研室，石家庄 050091

摘要

血管外膜作为调节血管功能关键因子的生成、储存和释放的重要部位，在某些条件下被认为可能是血管壁的损伤感受组织。外膜细胞通常首先响应血管应激或损伤，进而影响血管壁的结构和功能。越来越多的证据表明，在低氧及相关的肺动脉高压、动脉粥样硬化等疾病引起的血管重塑过程中外膜的改变是最早、最突出的。成纤维细胞在血管对局部微环境改变的适应调节方面发挥了重要的作用。本文重点就血管外膜在低氧诱导血管重塑中的作用及其可能的分子机制进行综述。

关键词： 外膜; 低氧; 成纤维细胞; 滋养血管; 低氧诱导因子-1α

分类号：R331；R543

The role of adventitia in hypoxic vascular remodeling

YU Fu-Yang, YANG Sheng-Chang, JI En-Sheng^*

Department of Physiology, College of Basic Medicine, Hebei University of Chinese Medicine, Shijiazhuang 050091, China

Abstract

As an important site for the production, storage and release of key regulators for vascular function, the vascular adventitia is thought to be a damage sensing tissue in the vascular wall under certain conditions. The adventitial cells are usually the first ones to respond to vascular stress or injury, and consequently affect the structure and function of blood vessel wall. Growing lines of evidence have shown that the vascular adventitia exhibits the earliest and most prominent changes in vascular remodeling due to hypoxia and related pulmonary hypertension and atherosclerosis. In particular, fibroblasts play an important role in the adaptation and regulation to local microenvironmental changes. This review focuses on the role of vascular adventitia in hypoxia-induced vascular remodeling and the underlying molecular mechanisms.

Key words: adventitia; hypoxia; fibroblast; vasa vasorum; hypoxia inducible factor-1α

收稿日期：2017-08-30　　录用日期：2018-03-21

通讯作者：吉恩生　　E-mail: jesphy@126.com

DOI: 10.13294/j.aps.2018.0025

引用本文：

于富洋, 杨胜昌, 吉恩生. 血管外膜在低氧性血管重塑中的作用[J]. 生理学报 2018; 70 (2): 211-216.

YU Fu-Yang, YANG Sheng-Chang, JI En-Sheng. The role of adventitia in hypoxic vascular remodeling. Acta Physiol Sin 2018; 70 (2): 211-216 (in Chinese with English abstract).