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细胞焦亡与脑卒中

唐标, 邓常清^*

湖南中医药大学医学院，长沙 410028

摘要

细胞焦亡是一种依赖于caspase-1和caspase-4/5/11的程序性细胞死亡方式，参与感染性疾病和神经系统疾病等的发展过程。细胞焦亡主要由经典炎症小体途径和非经典炎症小体途径介导，而经典炎症小体途径在脑卒中中活化并且加重脑损伤，抑制炎症小体和下游分子能减轻损伤发挥保护作用。经典炎症小体途径介导了脑卒中损伤，因而焦亡成为脑卒中干预的潜在靶点。本文就细胞焦亡与脑卒中关系的研究进展进行综述，旨在为相关领域的研究提供参考。

关键词： 细胞焦亡; 炎症小体; 脑卒中

分类号：R329

Pyroptosis and stroke

TANG Biao, DENG Chang-Qing^*

Medical School, Hunan University of Chinese Medicine, Changsha 410028, China

Abstract

Pyroptosis is a form of inflammatory programmed cell death activated by caspase-1 and caspase-4/5/11, and involves in the pathogenesis of infectious diseases and nervous system diseases. Pyroptosis is mediated by canonical inflammasome pathway and non-canonical inflammasome pathway. The canonical inflammasome pathway is activated in stroke and aggravates brain injury. Inhibition of inflammasome, caspase-1, IL-1β and IL-18 ameliorates brain injury. These studies indicate that canonical inflammasome pathway contributes to post-stroke brain injury, therefore, pyroptosis has become a potential therapeutic target for preventing excessive cell death during stroke. We reviewed the relationship between pyroptosis and stroke to provide some perspectives on future researches in this field.

Key words: pyroptosis;;

收稿日期：2017-09-20　　录用日期：2017-12-25

通讯作者：邓常清　　E-mail: dchangq@sohu.com

DOI: 10.13294/j.aps.2017.0091

引用本文：

唐标, 邓常清. 细胞焦亡与脑卒中[J]. 生理学报 2018; 70 (1): 93-98.

TANG Biao, DENG Chang-Qing. Pyroptosis and stroke. Acta Physiol Sin 2018; 70 (1): 93-98 (in Chinese with English abstract).