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甲烷抗炎、抗氧化和抗凋亡生物学效应的研究进展

胡静芸¹, 蔡明², 王茜¹, 娄淑杰^1,*

¹上海体育学院运动人体科学学院，上海 200438；²上海健康医学院康复学院，上海 201318

摘要

甲烷(CH4)是结构最简单的碳氢化合物，之前认为只有哺乳动物的口腔和胃肠道中的产甲烷菌才能生成CH4。但是近年来研究显示，动物体内的胆碱及其代谢物也能分解或转变成CH4，这种内源性CH4具有保护细胞膜免受活性氧(reactive oxygen species, ROS)的攻击以及促进细胞膜修复的作用。此外，外源性CH4具有较强的抗炎、抗氧化、抗凋亡的生物学效应，提高脑、心脏、肝脏等多种组织器官的抗氧化能力，减轻其氧化应激损伤和炎症损伤的程度，对多种临床疾病的治疗具有研究和应用价值。因此，本文综述近年来CH4在哺乳动物体内的合成代谢及其抗炎、抗氧化和抗凋亡的生物学功能方面的最新研究进展，为预防和治疗氧化应激相关疾病的研究提供新的治疗策略和切入点。

关键词： 甲烷; 合成代谢; 抗炎; 抗氧化; 小分子气体

分类号：R3

Research advances on anti-inflammatory, antioxidant and anti-apoptotic biological effects of methane

HU Jing-Yun¹, CAI Ming², WANG Qian¹, LOU Shu-Jie^1,*

¹School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China；²School of Rehabilitation, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China

Abstract

Methane (CH4) is the simplest hydrocarbons and endogenous CH4 has been thought only to be generated by methanogens in the oral cavity and gastrointestinal tract of the mammals. However, recent animal studies have shown that endogenous CH4 can also be generated from choline and its metabolites in the mammals to protect the plasma membrane from reactive oxygen species attack and repair the membrane. In addition, exogenous CH4 can ameliorate the oxidative stress injury of multiple tissues and organs through its anti-inflammatory, antioxidant and anti-apoptosis effects. This paper reviews the recent researches about CH4 synthetic metabolism and biological functions, and highlights its potential of wide application in the prevention and treatment of oxidative stress related diseases and the significance for the development of gas medicine.

Key words: CH4;;;;

收稿日期：2017-07-03　　录用日期：2018-01-11

通讯作者：娄淑杰　　E-mail: shujielou319@163.com

DOI: 10.13294/j.aps.2018.0007

引用本文：

胡静芸, 蔡明, 王茜, 娄淑杰. 甲烷抗炎、抗氧化和抗凋亡生物学效应的研究进展[J]. 生理学报 2018; 70 (1): 85-92.

HU Jing-Yun, CAI Ming, WANG Qian, LOU Shu-Jie. Research advances on anti-inflammatory, antioxidant and anti-apoptotic biological effects of methane. Acta Physiol Sin 2018; 70 (1): 85-92 (in Chinese with English abstract).