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抑郁症共病胃肠疾病的神经生物学机制研究进展

张涛^1,2, 令狐婷^1,2,3, 张潇^1,2,3, 田俊生^1,2,*, 秦雪梅^1,2

¹山西大学中医药现代研究中心，太原 030006；²山西大学地产中药功效物质研究与利用山西省重点实验室，太原 030006；³山西大学化学化工学院，太原 030006

摘要

抑郁症是一种常见的心境障碍性疾病，对人群健康的危害日益加重。胃肠疾病是一类兼具动力学改变和器质性病变的系列疾病，主要包括功能性胃肠病、胃食管反流病、胃炎、胃溃疡。近年来，抑郁症共病胃肠疾病的现象普遍，但是在临床诊疗过程中，患者多被医生诊断为单方面抑郁症或胃肠疾病，造成患者治疗延迟，甚至无效。本文综述了抑郁症共病胃肠疾病的一些临床症状表现，并以两者涉及的可能发病机制为出发点，找寻其共病的神经生物学通路，从而提高人们对抑郁症共病胃肠疾病的重视程度，并为共病的临床与基础研究及兼具治疗作用的药物研发提供依据。

关键词： 抑郁症; 胃肠疾病; 共病; 神经生物学通路; 发病机制

分类号：R338; R57; R74

Advances in neurobiological mechanisms of comorbid depression and gastro- intestinal disease

Zhang Tao^1,2, LINGHU Ting^1,2,3, ZHANG Xiao^1,2,3, TIAN Jun-Sheng^1,2,*, QIN Xue-Mei^1,2

¹Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China；²Shanxi Key Laboratory of Active Constituents Research and Utilization of TCM, Shanxi University, Taiyuan 030006, China；³College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China

Abstract

Depression is a common mood disorder, which is harmful to public health critically. Gastrointestinal diseases are a series of diseases with both dynamic changes and organic disease, including functional gastrointestinal disease, gastroesophageal reflux disease, gastritis, and gastric ulcer. In recent years, the phenomena of comorbid depression and gastrointestinal disease have become common, however, most patients were diagnosed as unilateral depression or gastrointestinal disease in the clinical treatment process, resulting in delayed treatment or even invalid. The present review focuses on some of the clinical symptoms of comorbid depression and gastrointestinal disease, and begins to explore the possible pathogenesis, so as to find out the potential neurobiological pathways of comorbidity. Consequently, the more attention on comorbid depression and gastrointestinal disease will be paid, and the clinical and basic research of comorbidity and the drug development will be provided.

Key words: depression;;;;

收稿日期：2017-07-19　　录用日期：2018-01-11

通讯作者：田俊生　　E-mail: jstian@sxu.edu.cn

DOI: 10.13294/j.aps.2018.0004

引用本文：

张涛, 令狐婷, 张潇, 田俊生, 秦雪梅. 抑郁症共病胃肠疾病的神经生物学机制研究进展[J]. 生理学报 2018; 70 (1): 71-78.

Zhang Tao, LINGHU Ting, ZHANG Xiao, TIAN Jun-Sheng, QIN Xue-Mei. Advances in neurobiological mechanisms of comorbid depression and gastro- intestinal disease. Acta Physiol Sin 2018; 70 (1): 71-78 (in Chinese with English abstract).