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高密度脂蛋白对中性粒细胞功能调节作用的研究进展

王治洲¹, 项红², 夏士林³, 尚东^1,*

¹大连医科大学附属第一医院，大连 116000；²大连医科大学中西医结合学院(研究院)，大连 116000；³大连医科大学附属第一医院辽宁省高校中西医结合外科疑难危重病重点实验室，大连 116000

摘要

长期以来，关于高密度脂蛋白(high-density lipoprotein, HDL)对炎症细胞调节作用的研究集中在以冠状动脉粥样硬化性心脏病为主的心血管疾病领域。近年来，关于HDL对炎症细胞调节作用的研究已扩展到糖尿病、代谢性疾病、慢性肾脏病、系统性炎症疾病、自身免疫病及感染性疾病等多个领域。研究显示，HDL可以通过影响激活的中性粒细胞细胞因子合成、变形运动、黏附、迁移及消灭病原体进而抑制其功能。临床研究表明，低HDL水平的健康男性体内血清HDL水平与中性粒细胞/淋巴细胞比值(neutrophil-to-lymphocyte ratio, NLR)呈负相关，且伴持续性器官衰竭的重症急性胰腺炎患者血清HDL水平与病情严重程度存在密切关系。因此，了解HDL对中性粒细胞功能的调节作用及机制对治疗中性粒细胞过度激活所致疾病具有重要的临床价值。

关键词： 高密度脂蛋白; 载脂蛋白A-I ; 中性粒细胞

分类号：R363;R392.12

Research progress in the modulating effect of high-density lipoprotein on neutrophil function

WANG Zhi-Zhou¹, XIANG Hong², XIA Shi-Lin³, SHANG Dong^1,*

¹The First Affiliated Hospital, Dalian Medical University, Dalian 116000, China；²College (Institute) of Integrative Medicine, Dalian Medical University, Dalian 116000, China；³Key Laboratory of Integrated Medicine Research for Surgery Severity Diseases of Liaoning Provincial Education Department, Dalian Medical University, Dalian 116000, China

Abstract

For a long period, studies about the modulating effect of high-density lipoprotein (HDL) on inflammatory cells mainly focus on cardiovascular diseases. In recent years, researchers have found the significant role of HDL in many other fields, such as diabetes, metabolic syndrome, chronic kidney disease, systemic inflammatory disease, autoimmune diseases and infectious diseases. Researches have shown that HDL can inhibit the function of activated neutrophil via disturbing the cytokine production, deformation, adhesion, transmigration and pathogen elimination. Clinical trials have discovered that serum HDL level is negatively correlated with neutrophil-to-lymphocyte ratio in healthy males with low HDL level. In addition, serum HDL level is closely associated with disease severity of severe acute pancreatitis. Consequently, understanding the effect and mechanism of the regulation of HDL on neutrophil function plays an important role in remedying the diseases resulted from excessively activated neutrophil.

Key words: high-density lipoprotein; apolipoprotein A-I ; neutrophil

收稿日期：2017-06-06　　录用日期：2017-09-30

通讯作者：尚东　　E-mail: shangdong@dmu.edu.cn

DOI: 10.13294/j.aps.2017.0077

引用本文：

王治洲, 项红, 夏士林, 尚东. 高密度脂蛋白对中性粒细胞功能调节作用的研究进展[J]. 生理学报 2017; 69 (6): 852-860.

WANG Zhi-Zhou, XIANG Hong, XIA Shi-Lin, SHANG Dong. Research progress in the modulating effect of high-density lipoprotein on neutrophil function. Acta Physiol Sin 2017; 69 (6): 852-860 (in Chinese with English abstract).