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中性粒细胞参与调控血管新生进程

韩健美, 勾萌, 肖蓉^*

辽宁师范大学生命科学学院，大连 116081

摘要

中性粒细胞是人类血液循环系统中最丰富的白细胞，能够提供持续的免疫监视活动。近年研究表明中性粒细胞与血管新生的关系十分密切。中性粒细胞可通过释放多种细胞因子，直接或间接地影响内皮细胞的生长以及迁移等过程，进而调控血管新生进程。本文针对中性粒细胞在调控血管新生过程中的重要作用及机制进行分析和归纳，以期为今后以中性粒细胞为靶点进行相关疾病的治疗提供线索。

关键词： 中性粒细胞; 血管新生 ; 血管内皮生长因子 ; 信号通路

分类号：Q291

Neutrophils regulate the process of angiogenesis

HAN Jian-Mei, GOU Meng, XIAO Rong^*

School of Life Science, Liaoning Normal University, Dalian 116081, China

Abstract

Neutrophils are one of the most abundant leukocytes present in the human blood circulation system, which could provide continuous immune surveillance. Recent studies have shown that neutrophils are closely related to angiogenesis. Neutrophils could release various cytokines, which regulate the angiogenic process by affecting the growth and migration of endothelial cells directly or indirectly. In the present review, the regulatory effects of neutrophils on angiogenic process and mechanisms are analyzed and summarized, which would provide clues for the treatment of related diseases using neutrophils as the targets in the future.

Key words: Neutrophils; angiogenesis ; vascular endothelial growth factor ; signal pathway

收稿日期：2017-05-04　　录用日期：2017-08-30

通讯作者：肖蓉　　E-mail: xiaorong_lnnu@126.com

DOI: 10.13294/j.aps.2017.0059

引用本文：

韩健美, 勾萌, 肖蓉. 中性粒细胞参与调控血管新生进程[J]. 生理学报 2017; 69 (6): 843-851.

HAN Jian-Mei, GOU Meng, XIAO Rong. Neutrophils regulate the process of angiogenesis. Acta Physiol Sin 2017; 69 (6): 843-851 (in Chinese with English abstract).