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认知功能研究中神经振荡交叉节律耦合应用研究进展

张力新, 王发颀, 王玲, 杨佳佳^*, 万柏坤

天津大学精密仪器与光电子工程学院，天津 300072

摘要

神经振荡交叉节律耦合(cross-frequency coupling, CFC)指不同神经元集群振荡节律之间的交叉调制作用，反映了大脑在不同时空尺度的局部场电位、脑电等神经电生理活动信息的传递与交流机制，是认知神经功能研究的重要工具。本文简要介绍了CFC基本现象与类型，并综述了在动物与人类认知功能研究的典型应用，归纳了现存的主要问题并展望其未来研究动向，以期为促进相关研究与应用提供新思路。

关键词： 神经振荡; 脑电 ; 局部场电位 ; 交叉节律耦合 ; 认知功能

分类号：Q42;R338;R318

Progress in the application of neural oscillations cross-frequency coupling in cognitive function research

ZHANG Li-Xin, WANG Fa-Qi, Wang Ling, YANG Jia-Jia^*, WAN Bai-Kun

School of Precision Instrument and Opto-Electronics Engineering, Tianjin University, Tianjin 300072, China

Abstract

Neural oscillations cross-frequency coupling (CFC) refers to the effect of the cross modulation between the electrophysiological oscillation rhythm in different ensembles of neurons. The CFC can reflect the mechanism of information transfer and exchange of local field potentials, electroencephalograph (EEG) and other neural electrophysiological activities at different spatial and temporal scales and plays an important role in the study of cognitive function. This paper introduces the basic phenomenon and classifications of neural oscillation CFC briefly, and reviews the typical applications in the study of the animal cognition model and human cognitive function in recent years, respectively. The main problems are also summarized and the future research is prospected in order to provide new ideas to promote the study and application of the CFC.

Key words: neural oscillation; electroencephalograph ; local field potential ; cross-frequency coupling ; cognitive function

收稿日期：2017-03-25　　录用日期：2017-07-04

通讯作者：杨佳佳　　E-mail: jiajia.yang@tju.edu.cn

DOI: 10.13294/j.aps.2017.0041

引用本文：

张力新, 王发颀, 王玲, 杨佳佳, 万柏坤. 认知功能研究中神经振荡交叉节律耦合应用研究进展[J]. 生理学报 2017; 69 (6): 805-816.

ZHANG Li-Xin, WANG Fa-Qi, Wang Ling, YANG Jia-Jia, WAN Bai-Kun. Progress in the application of neural oscillations cross-frequency coupling in cognitive function research. Acta Physiol Sin 2017; 69 (6): 805-816 (in Chinese with English abstract).