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肺的血小板生成功能

周艳, 黄艳红, 罗自强^*

中南大学基础医学院生理学系，长沙 410013

摘要

人们通常认为，血小板是从骨髓成熟的巨核细胞胞质裂解脱落下来的具有生物活性的小块胞质。虽然研究者早已发现在肺组织中存在大量巨核细胞，但肺是否具有生成血小板的功能一直存在争议。本文主要就肺的血小板生成功能假说的提出、早期研究过程、最新研究证据及可能的意义进行简要综述。

关键词： 巨核细胞; 血小板 ; 肺造血功能

分类号：R331; R332

The platelet-producing function of lung

ZHOU Yan, HUANG Yan-Hon, LUO Zi-Qiang^*

Department of Physiology, School of Basic Medical Science, Central South University, Changsha 410013, China

Abstract

It is generally believed that platelets are cytoplasmic bodies with biological activity falling off the cytoplasm of megakaryocytes from bone marrow. However, a large number of megakaryocytes have been found in the lung tissue in many researches. Whether the lung has the function of producing platelets has been controversial. In this paper, we briefly review the proposition, early stage researches, the latest confirmations and possible meaning of the hypothesis of platelet-producing function of lung.

Key words: Megakaryocytes; platelets ; pulmonary hematopoietic function

收稿日期：2017-06-07　　录用日期：2017-09-11

通讯作者：罗自强　　E-mail: luozq1962@163.com

DOI: 10.13294/j.aps.2017.0061

引用本文：

周艳, 黄艳红, 罗自强. 肺的血小板生成功能[J]. 生理学报 2017; 69 (5): 730-734.

ZHOU Yan, HUANG Yan-Hon, LUO Zi-Qiang. The platelet-producing function of lung. Acta Physiol Sin 2017; 69 (5): 730-734 (in Chinese with English abstract).