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大麻素受体系统对视网膜细胞离子通道和突触传递的调控

王少六¹, 钱文静², 王霄汉², 汪书越², 杨薇², 张传强², 王中峰^2,*

¹洛阳职业技术学院，洛阳 471000；²复旦大学脑科学研究院，医学神经生物学国家重点实验室，脑科学协同创新中心，上海 200032

摘要

内源性大麻素系统在脊椎动物视网膜中广泛分布。大麻素受体(cannbinoid receptor)主要有CB1和CB2两个亚型，与内源性配体N-花生四烯酸氨基乙醇(N-arachidonoylethanolamide, anandamine, AEA)和2-花生四烯酸甘油(2-arachidonyl glycerol, 2-AG)结合调控视网膜神经元和胶质细胞的功能，从而参与调控视网膜视觉信息的处理。本文结合我们研究组近年在视网膜大麻素受体系统的研究结果，综述了有关大麻素CB1和CB2受体对视网膜细胞离子通道和突触传递调控及其机制的研究进展。

关键词： CB1受体; CB2受体 ; 视网膜 ; 电压门控钙通道 ; 钾通道 ; 突触传递

分类号：Q436；R339.14+6

Cannabinoid receptor system regulates ion channels and synaptic transmission in retinal cells

WANG Shao-Liu¹, QIAN Wen-Jing², WANG Xiao-Han², WANG Shu-Yue², YANG Wei², ZHANG Chuan-Qiang², WANG Zhong-Feng^2,*

¹Luoyang Vocational and Technical College, Luoyang 471000, China；²Institutes of Brain Science, State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain Science, Fudan University, Shanghai 200032, China

Abstract

Endocannabinoid receptor system is extensively expressed in the vertebrate retina. There are two types of cannabinoid receptors, CB1 and CB2. Activation of these two receptors by endocannabinoids N-arachidonoylethanolamide (anandamine, AEA) and 2-arachidonyl glycerol (2-AG) regulates multiple neuronal and glial ion channels, thus getting involved in retinal visual information processing. In this review, incorporating our results, we discuss the modulation of cannabinoid CB1 and CB2 receptors on retinal neuronal and glial ion channels and retinal synaptic transmission.

Key words: CB1 receptor; CB2 receptor ; retina ; voltage-gated Ca2+ channels ; K+ channels ; synaptic transmission

收稿日期：2017-04-19　　录用日期：2017-09-11

通讯作者：王中峰　　E-mail: zfwang@fudan.edu.cn

DOI: 10.13294/j.aps.2017.0064

引用本文：

王少六, 钱文静, 王霄汉, 汪书越, 杨薇, 张传强, 王中峰. 大麻素受体系统对视网膜细胞离子通道和突触传递的调控[J]. 生理学报 2017; 69 (5): 685-692.

WANG Shao-Liu, QIAN Wen-Jing, WANG Xiao-Han, WANG Shu-Yue, YANG Wei, ZHANG Chuan-Qiang, WANG Zhong-Feng. Cannabinoid receptor system regulates ion channels and synaptic transmission in retinal cells. Acta Physiol Sin 2017; 69 (5): 685-692 (in Chinese with English abstract).