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补体C1q/肿瘤坏死因子相关蛋白3的研究进展

张城林, 吴立玲^*, 李丽

北京大学医学部生理学与病理生理学系，北京100191

摘要

补体C1q/肿瘤坏死因子相关蛋白3 (complement-C1q/tumor necrosis factor-related protein 3, CTRP3)是2003年发现的脂肪因子，是CTRP家族的重要成员之一。CTRP3在多种组织和细胞类型中均有表达，且在不同物种间具有较高的保守性。随着近年来对其研究的深入，CTRP3的多种新功能被逐渐揭示。CTRP3不仅可以调节软骨细胞增殖及多种骨关节疾病，还对机体睾酮和脂肪因子的分泌、糖脂代谢、线粒体生物合成、炎症反应、细胞凋亡、血管新生、血管钙化以及心室重塑等多种生理和病理过程具有调节作用。本文重点综述了CTRP3的发现、基因和蛋白结构、表达调控以及生物学功能等方面的研究现状，希望可以为CTRP3的进一步研究提供新的思路。

关键词： 补体C1q/肿瘤坏死因子相关蛋白3; 骨关节疾病 ; 炎症反应 ; 代谢性疾病 ; 心血管疾病

分类号：R363

Research progress of complement-C1q/tumor necrosis factor-related protein 3

ZHANG Cheng-Lin, WU Li-Ling^*, Li Li

Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing 100191, China

Abstract

Complement-C1q/tumor necrosis factor-related protein 3 (CTRP3) is an adipokine that primarily identified in 2003 and is an important member of CTRP family. CTRP3 is expressed in various tissues and cell types, and is highly conserved among different species. Multiple novel functions of CTRP3 have been reported recently as the further research on this protein develops. CTRP3 not only affects the proliferation of chondrocytes and the pathogenesis of osteoarthritis, but also regulates multiple physiological and pathological processes including the secretion of testosterone and adipokines, glucose and lipid metabolism, mitochondrial biogenesis, inflammatory response, cell apoptosis, angiogenesis, vascular calcification and ventricular remodeling. The present review mainly focuses on the research progresses on CTRP3, including its discovery, gene and protein structure, expression regulation, and biological functions. The progresses summarized may provide new clues for the further investigation of CTRP3.

Key words: complement-C1q/tumor necrosis factor-related protein 3; osteoarthritis ; inflammation ; metabolic diseases ; cardiovascular diseases

收稿日期：2017-03-10　　录用日期：2017-05-26

通讯作者：吴立玲　　E-mail: pathophy@bjmu.edu.cn; lilyby@163.com

DOI: 10.13294/j.aps.2017.0032

引用本文：

张城林, 吴立玲, 李丽. 补体C1q/肿瘤坏死因子相关蛋白3的研究进展[J]. 生理学报 2017; 69 (5): 666-676.

ZHANG Cheng-Lin, WU Li-Ling, Li Li. Research progress of complement-C1q/tumor necrosis factor-related protein 3. Acta Physiol Sin 2017; 69 (5): 666-676 (in Chinese with English abstract).