过刊浏览

缰核的结构和功能

张白冰^1,2, 杜久林^1,2,3,*

¹中国科学院神经科学研究所，中国科学院脑科学与智能技术卓越创新中心，神经科学国家重点实验室，上海 200031；²中国科学院大学，北京 100049；³上海科技大学生命科学与技术学院，上海 200031

摘要

缰核是脊椎动物进化上高度保守的一个大脑核团。缰核被认为是情绪相关行为控制或调节的一个关键节点，参与调节焦虑、恐惧、奖赏、抑郁、尼古丁成瘾等行为。一方面，行为选择和情感相关的神经信息主要分别通过基底神经节和边缘系统输入到缰核；同时，缰核还接受多种感觉模态信息的输入。其中，缰核的视觉输入来源于视网膜神经节细胞(retina ganglion cells, RGCs)和丘脑构成的视觉通路，参与到斑马鱼的亮偏好行为(light-preference behavior)中。另一方面，缰核主要投射到多巴胺能系统和5-羟色胺能神经调质系统。正是由于缰核既接受动物内在情绪信息的输入，又接受外界感觉信息的输入，同时支配多巴胺和5-羟色胺等重要的调质系统，其神经功能表现出多样性和复杂性。本文从缰核的结构和神经连接入手，综述了目前已知的缰核神经功能及其结构基础，并进一步探讨了未来重要的研究方向。

关键词： 缰核; 神经调质 ; 神经连接 ; 神经功能 ; 行为

分类号：R338

The structure and function of habenula

ZHANG Bai-Bing^1,2, DU Jiu-Lin^1,2,3,*

¹Institute of Neuroscience, State Key Laboratory of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China；²University of Chinese Academy of Sciences, Beijing 100049, China；³School of Life Science and Technology, ShanghaiTech University, Shanghai 200031, China

Abstract

The habenula (Hb) is an evolutionarily conserved diencephalic structure in vertebrates. It is considered as an emotion center and plays critical roles in regulating diverse types of emotion-related behaviors, including anxiety, fear, reward, depression, and nicotine withdrawal. On the one hand, action selection- and emotion-relevant inputs are transferred to the Hb through the basal ganglia and limbic system, respectively. At the same time, sensory inputs of multiple modalities also converge on the Hb. Among them, the visual input of the Hb from the retina ganglion cells ‒ thalamus pathway has been found to play a critical role in light-preference behavior of zebrafish. On the other hand, the Hb projects to two main neuromodulatory systems, the dopaminergic system and the serotoninergic system. As the Hb receives both internal emotion inputs and external sensory inputs and regulates the function of neuromodulatory systems, its functions are quite diverse and complex. In this review, we summarize the progress in both the structure and connection of the Hb and propose future study direction.

Key words: Habenula; neuromodulator ; neural connection ; neural function ; behavior

收稿日期：2017-04-27　　录用日期：2017-09-12

通讯作者：杜久林　　E-mail: forestdu@ion.ac.cn

DOI: 10.13294/j.aps.2017.0065

引用本文：

张白冰, 杜久林. 缰核的结构和功能[J]. 生理学报 2017; 69 (5): 623-636.

ZHANG Bai-Bing, DU Jiu-Lin. The structure and function of habenula. Acta Physiol Sin 2017; 69 (5): 623-636 (in Chinese with English abstract).