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缺血性心脏病的线粒体质量控制及迷走神经干预

薛润青, 徐曼, 于晓江, 刘龙珠, 臧伟进^*

西安交通大学医学部基础医学院药理学系，西安 710061

摘要

缺血性心脏病(ischemic heart disease, IHD)是危害人类健康的首要疾病。线粒体是细胞内能量供应和信息整合的中心，决定细胞的生存和/或死亡。线粒体质量控制是指线粒体分裂与融合、线粒体自噬等动态调节过程。新近研究显示，增强线粒体质量控制对维持线粒体健康以及心肌功能至关重要，而线粒体质量控制任何一个环节的紊乱都将导致心肌缺血损伤的发生和发展。本文就线粒体质量控制及其在IHD中的研究进展作一综述，并结合本实验室研究成果，阐述迷走神经干预改善IHD的线粒体质量控制相关机制

关键词： 线粒体质量控制; 线粒体动力学 ; 线粒体自噬 ; 缺血性心脏病 ; 迷走神经

分类号：R3

Recent progress of mitochondrial quality control in ischemic heart disease and its role in cardio-protection of vagal nerve

XUE Run-Qing, XU Ma, YU Xiao-Jiang , LIU Long-Zhu, ZANG Wei-Jin^*

Department of Pharmacology, Xi’an Jiaotong University Health Science Center, Xi’an 710061, China

Abstract

Ischemic heart disease (IHD) is the life-threatening cardiovascular disease. Mitochondria have emerged as key participants and regulators of cellular energy demands and signal transduction. Mitochondrial quality is controlled by a number of coordinated mechanisms including mitochondrial fission, fusion and mitophagy, which plays an important role in maintaining healthy mitochondria and cardiac function. Recently, dysfunction of each process in mitochondrial quality control has been observed in the ischemic hearts. This review describes the mechanism of mitochondrial dynamics and mitophagy as well as its performance linked to myocardial ischemia. Moreover, in combination with our study, we will discuss the effect of vagal nerve on mitochondria in cardio-protection.

Key words: mitochondrial quality control; mitochondrial dynamics ; mitophagy ; ischemic heart disease ; vagal nerve

收稿日期：2017-04-24　　录用日期：2017-08-25

通讯作者：臧伟进　　E-mail: zwj@xjtu.edu.cn

DOI: 10.13294/j.aps.2017.0056

引用本文：

薛润青, 徐曼, 于晓江, 刘龙珠, 臧伟进. 缺血性心脏病的线粒体质量控制及迷走神经干预[J]. 生理学报 2017; 69 (5): 579-586.

XUE Run-Qing, XU Ma, YU Xiao-Jiang , LIU Long-Zhu, ZANG Wei-Jin. Recent progress of mitochondrial quality control in ischemic heart disease and its role in cardio-protection of vagal nerve. Acta Physiol Sin 2017; 69 (5): 579-586 (in Chinese with English abstract).