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前额叶皮层和纹状体的局域场电位的功率编码奖励信息

陈钰莹, 潘晓川, 王如彬, SAKAGAMI Masamichi

华东理工大学认知神经动力学研究所，上海 200237；日本玉川大学脑科学研究所，东京194-8610

摘要

前额叶皮层和纹状体是大脑内两个重要的区域，研究表明它们都参与了许多高级认知过程，如学习记忆、奖励信息处理、行为决策等。单细胞电生理记录实验已显示前额叶皮层和纹状体的神经元能够编码奖励信息，但不清楚这两个区域的局域场电位(local field potential, LFP)是否也能编码奖励信息。为研究这个问题，当猴子在进行一个奖励预测实验时，用多通道电极同时记录了前额叶皮层和纹状体的LFP。采用短时傅里叶变换，将记录的LFP转换为时、频域上的信号，比较不同奖励条件(大容量水奖励和小容量水奖励)下功率值的分布。结果显示前额叶皮层和纹状体的LFP的功率能够区分不同的奖励条件，并且小容量水奖励条件下的功率值大于大容量水奖励条件下的功率值；进一步研究显示LFP在β频段(14~30 Hz)能更好地编码奖励信息。以上结果表明前额叶皮层和纹状体的LFP能够有效地编码奖励信息，有助于进一步理解LFP在处理奖励信息过程中的作用。

关键词： 前额叶皮层; 纹状体 ; 奖励预测 ; 局域场电位 ; 非参数置换检验

分类号：Q427

Reward information encoded by power of local field potentials in the primate prefrontal cortex and striatum

CHEN Yu-Ying, PAN Xiao-Chuan, WANG Ru-Bin, SAKAGAMI Masamichi

Institute of Cognitive Neurodynamics, East China University of Science and Technology, Shanghai 200237, China； Brain Science Institute, Tamagawa University, Tokyo 194-8610, Japan

Abstract

Prefrontal cortex and striatum are two major areas in the brain. Some research reports suggest that both areas are involved in many advanced cognitive processes, such as learning and memory, reward processing, and behavioral decision. Single-unit recording experiments have found that neurons in the prefrontal cortex and striatum can represent reward information, but it remains elusive whether and how local field potentials (LFPs) in the two areas encode reward information. To investigate these issues, we recorded LFPs simultaneously in the prefrontal cortex and striatum of two monkeys by performing a reward prediction task (a large amount reward vs a small amount reward). Recorded LFP signals were transformed from the time domain to the time and frequency domain using the method of short-time Fourier transform (STFT). We calculated the power in each frequency and time, and examined whether they were different in the two reward conditions. The results showed that power of LFPs in both the prefrontal cortex and striatum distinguished one reward condition from the other one. And the power in small reward trials was greater than that in large reward trials. Furthermore, it was found that the LFPs better encoded reward information in the beta band (14–30 Hz) rather than other frequency bands. Our results suggest that the LFPs in the prefrontal cortex and striatum effectively represent reward information, which would help to further understand functional roles of LFPs in reward processing.

Key words: Prefrontal cortex; striatum ; reward prediction ; local field potential ; nonparametric permutation test

收稿日期：2016-12-16　　录用日期：2017-04-17

通讯作者：潘晓川　　E-mail: pxc@ecust.edu.cn

引用本文：

陈钰莹, 潘晓川, 王如彬, SAKAGAMI Masamichi. 前额叶皮层和纹状体的局域场电位的功率编码奖励信息[J]. 生理学报 2017; 69 (4): 385-396.

CHEN Yu-Ying, PAN Xiao-Chuan, WANG Ru-Bin, SAKAGAMI Masamichi. Reward information encoded by power of local field potentials in the primate prefrontal cortex and striatum. Acta Physiol Sin 2017; 69 (4): 385-396 (in Chinese with English abstract).