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钾通道与乳腺癌细胞的增殖和转移

张磊, 邹伟, 周士胜, 陈冬冬

辽宁师范大学生命科学学院，大连 116029；大连大学医学院，大连 116600

摘要

K+ 通道是细胞膜上一类特殊的蛋白质离子孔道，参与细胞内多种重要的生理活动的调节。近年来发现，K+ 通道不仅与神经系统、心血管系统疾病相关，而且可以作为治疗通道疾病的靶点。许多研究表明，K+ 通道基因在乳腺癌和其它肿瘤形成过程中还具有原癌基因特性，其编码的蛋白决定着细胞的增殖、癌变、侵袭和转移。本文概括介绍了K+ 通道与乳腺癌的发生、肿瘤细胞增殖和转移等方面的研究进展。

关键词： K+通道; 乳腺癌; 增殖; 转移

分类号：Q7

Potassium channels and proliferation and migration of breast cancer cells

Zhang Lei, ZOU Wei, ZHOU Shi-Sheng, CHEN Dong-Dong

College of Life Science, Liaoning Normal University, Dalian 116029, China； Medical College of Dalian University, Dalian 116600, China

Abstract

Potassium channels (K+ channels), a family of special ion channel proteins, are involved in various physiological functions. Recent data show that the abnormalities of K+ channels are not only responsible for some neurological and cardiovascular diseases but also for channelopathies. Furthermore, many groups reported that the abnormalities of K+ channels had shown their oncogenic potential in breast introduction and other malignant tumors, promoting proliferation, invasion and metastasis. The aim of this review is to give an updated introduction of research progress in K+ channels associated with breast cancer.

Key words: potassium channels; breast cancer; proliferation; metastasis

收稿日期：2008-09-20　　录用日期：2008-12-22

通讯作者：邹伟　　E-mail: weizou60@126.com

引用本文：

张磊, 邹伟, 周士胜, 陈冬冬. 钾通道与乳腺癌细胞的增殖和转移[J]. 生理学报 2009; 61 (1): 15-20.

Zhang Lei, ZOU Wei, ZHOU Shi-Sheng, CHEN Dong-Dong. Potassium channels and proliferation and migration of breast cancer cells. Acta Physiol Sin 2009; 61 (1): 15-20 (in Chinese with English abstract).