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视网膜神经节细胞的电生理学研究进展

周旭娇, 王中峰, 吴继红

复旦大学附属眼耳鼻喉科医院实验中心，上海市视觉损害与重建重点实验室，上海 200031；复旦大学脑科学研究院，上海 200032

摘要

了解视网膜神经节细胞(retinal ganglion cells, RGCs)的电生理学特性及其影响因素，有助于深入了解其正常状态下独特的生理功能，对于从细胞功能学角度阐明青光眼等视神经变性疾病的发病机制具有重要意义。本文就近年来随着膜片钳技术的应用，有关RGCs电压门控离子通道、配体门控离子通道，以及一些神经调质对这些通道的影响等方面的研究进展作一综述。

关键词： 视网膜神经节细胞; 电压门控离子通道; 配体门控离子通道; 神经调质

分类号：R339.14+6;R775.9

[Progress in electrophysiological studies of retinal ganglion cells.] [Article in Chinese]

ZHOU Xu-Jiao, WANG Zhong-Feng, WU Ji-Hong

Research Center, Department of Ophthalmology at Eye &； ENT Hospital, Fudan University, Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai 200031, China； Institutes of Brain Science, Fudan University, Shanghai 200032, China

Abstract

The knowledge about electrophysiological properties of retinal ganglion cells (RGCs), as well as modulation of these properties, is important not only for understanding the unique physiological functions of RGCs under normal conditions, but also for exploring the cellular mechanisms of retinal neurodegeneration diseases, such as glaucoma. In this paper, we reviewed the progress in electrophysiological studies of RGCs by using patch-clamp techniques, concerning the voltage-gated ion channels, the ligand-gated ion channels and the effects of neuromodulators on these channels.

Key words: retinal ganglion cell; voltage-gated ion channels; ligand-gated ion channels; neuromodulator

收稿日期：2014-04-08　　录用日期：2014-06-17

通讯作者：王中峰,吴继红　　E-mail: lwnn2006@gmail.com, zfwang@fudan.edu.cn

引用本文：

周旭娇, 王中峰, 吴继红. 视网膜神经节细胞的电生理学研究进展[J]. 生理学报 2014; 66 (5): 511-518.

ZHOU Xu-Jiao, WANG Zhong-Feng, WU Ji-Hong. [Progress in electrophysiological studies of retinal ganglion cells.] [Article in Chinese]. Acta Physiol Sin 2014; 66 (5): 511-518 (in Chinese with English abstract).