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沉默信息调节因子1在阿尔茨海默病中的神经保护作用

杨小荣, 王锐, 秦花萍, 赵欣, 刘乃红, 张策^*

山西医科大学生理学系，国家重点学科、细胞生理学省部共建重点实验室，太原 030001

摘要

沉默信息调节因子1 (silent information regulator 1, SIRT1)作为NAD+依赖的脱乙酰基酶，参与基因转录、能量代谢以及细胞衰老过程的调节。近年研究显示，SIRT1具有明显的神经保护作用。但SIRT1在阿尔茨海默病(Alzheimer’s disease, AD)中如何发挥对神经元的调节及保护作用仍不甚明了。本文结合近年的研究，重点总结了SIRT1在AD中的神经保护作用及其可能的分子机制，为防治神经退行性疾病提供新思路。

关键词： 沉默信息调节因子1; 阿尔茨海默病; 神经保护

分类号：R338

[Neuroprotective role of silent information regulator 1 in Alzheimer's disease.] [Article in Chinese]

YANG Xiao-Rong, WANG Rui, QIN Hua-Ping, ZHAO Xin, LIU Nai-Hong, ZHANG Ce^*

Department of Physiology, National Key Disciplines, Key Laboratory for Cellular Physiology of Ministry of Education, Shanxi Medical University, Taiyuan 030001, China

Abstract

Silent information regulator 1 (SIRT1), an NAD+-dependent deacetylase, is involved in the regulation of gene transcription, energy metabolism and cell aging. Recent studies have showed that SIRT1 possesses neuroprotective effects, however, it is not very clear how SIRT1 exerts the neuroprotection in Alzheimer’s disease (AD). In this review, we summarized the neuroprotective role of SIRT1 in AD and its possible molecular mechanisms, proposing a novel strategy for preventing and treating neurodegeneration.

Key words: silent information regulator 1; Alzheimer's disease; neuroprotection

收稿日期：2011-03-08　　录用日期：2011-05-16

通讯作者：张策　　E-mail: cezh2002@yahoo.com

引用本文：

杨小荣, 王锐, 秦花萍, 赵欣, 刘乃红, 张策. 沉默信息调节因子1在阿尔茨海默病中的神经保护作用[J]. 生理学报 2011; 63 (4): 396-400.

YANG Xiao-Rong, WANG Rui, QIN Hua-Ping, ZHAO Xin, LIU Nai-Hong, ZHANG Ce. [Neuroprotective role of silent information regulator 1 in Alzheimer's disease.] [Article in Chinese]. Acta Physiol Sin 2011; 63 (4): 396-400 (in Chinese with English abstract).