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胞内钙信号作用的神经模型

沈荣, 帅建伟^*

四川文理学院计算机科学系，达州 635000；厦门大学物理系，理论物理与天体物理研究所，厦门 361005

摘要

细胞溶质内的游离钙离子在许多细胞活动中发挥着重要的作用。对于神经元，细胞膜上的神经电信号和胞内钙离子化学信号之间有着复杂的相互作用，每个神经元都可看作为一个含有细胞膜和内质网膜的双膜系统，而神经细胞的内质网则可视为神经元内的神经元。本综述探讨了神经元膜上神经电信号与内质网钙通道释放的胞内钙信号相耦合的动力学模型。我们认为，计算神经动力学的一个研究方向是考虑包含胞内钙动力学的神经元模拟，而且该研究前沿转向考虑胞内钙波扩散运动的空间神经元模型。包含内质网钙动力学的神经模型，尤其是考虑胞体和树突内钙扩散的空间神经元模型，将加深我们对神经动力学的认识。

关键词： 神经元; 离子通道; 钙信号; 噪音; 网络

Neuronal modeling with intracellular calcium signaling

SHEN Rong, SHUAI Jian-Wei^*

Department of Computer Science, Sichuan University of Arts and Science, Dazhou 635000, China； Department of Physics and Institute of Theoretical Physics and Astrophysics, Xiamen University, Xiamen 361005, China

Abstract

Cytosolic Ca2+ ions play an important role in the regulation of numerous aspects of cellular activity in virtually all cell types. There is a complex interaction between the neuronal electrical signals on plasma membrane and the chemical signals of intracellular calcium. Each neuron can be considered as a binary membrane system with plasma membrane and endoplasmic reticulum membrane, and the neuronal endoplasmic reticulum can be regarded as a neuron-within-a-neuron. This review explores the simulation modeling of neuronal dynamics mutually coupled with the intracellular calcium signaling released from endoplasmic reticulum through the inositol 1,4,5-trisphosphate receptor calcium channels. We show that a current trend is to include the intracellular calcium dynamics into the neuronal models, and the frontier of this research is now shifting to spatial neuronal models with diffusing intracellular calcium. It is expected that more important results will be obtained with the neuronal models incorporating the intracellular calcium dynamics, especially the spatial models considering the calcium diffusion both in soma and dendritic branches.

Key words: neuron; channel; calcium signals; noise; network

收稿日期：　　录用日期：

通讯作者：帅建伟　　E-mail: jianweishuai@xmu.edu.cn

引用本文：

沈荣, 帅建伟. 胞内钙信号作用的神经模型[J]. 生理学报 2011; 63 (5): 442-452.

SHEN Rong, SHUAI Jian-Wei. Neuronal modeling with intracellular calcium signaling . Acta Physiol Sin 2011; 63 (5): 442-452 (in Chinese with English abstract).