过刊浏览

模拟失重条件下肌梭的改变与肌肉萎缩关系的研究进展

赵雪红, 樊小力

湖北文理学院医学院机能学部，襄阳 441053；西安交通大学医学院生理教研室，西安 710061

摘要

探明失重/模拟失重状态下骨骼肌发生萎缩的机理，寻找出预防和治疗肌萎缩的有效措施，是航天医学亟待解决的重要课题之一。研究资料表明，肌梭功能活动的改变可能与失重性肌萎缩的发生、发展有着密切的联系。本研究组多年来，围绕着模拟失重条件下大鼠比目鱼肌肌梭的结构、代谢、功能等方面发生的改变展开了一系列研究。本文对我们已取得的一些主要研究成果和相关研究作一综述，以期从模拟失重条件下肌梭改变方面来探讨失重性肌萎缩的发生机制，为制定更有效的防治失重性肌萎缩的措施提供线索和依据。

关键词： 肌梭; 肌萎缩; 模拟失重

分类号：R852.22

[Relationship between simulated weightlessness-induced muscle spindle change and muscle atrophy.] [Article in Chinese]

ZHAO Xue-Hong, FAN Xiao-Li

Medical function Department, Medical College of Hubei University of Arts and Science. Xiangyang 441053, China； Department of Physiology, Medical College of Xi’an Jiaotong University, Xi’an 710061, China

Abstract

One of the most important and urgent issues in the field of space medicine is to reveal the potential mechanism underlying the disused muscle atrophy during the weightlessness or microgravity environment. It will conduce to find out effective methods for the prevention and treatment of muscle atrophy during a long-term space flight. Increasing data show that muscle spindle discharges are significantly altered following the hindlimb unloading, suggesting a vital role in the progress of muscle atrophy. In the last decades, we have made a series of studies on changes in the morphological structure and function of muscle spindle following simulated weightlessness. This review will discuss our main results and related researches for understanding of muscle spindle activities during microgravity environment, which may provide a theoretic basis for effective prevention and treatment of muscle atrophy induced by weightlessness.

Key words: muscle spindle; muscle atrophy; simulated weightlessness

收稿日期：2012-05-22　　录用日期：2012-09-28

通讯作者：樊小力　　E-mail: fanxl@mail.xjtu.edu.cn

引用本文：

赵雪红, 樊小力. 模拟失重条件下肌梭的改变与肌肉萎缩关系的研究进展[J]. 生理学报 2013; 65 (1): 96-100.

ZHAO Xue-Hong, FAN Xiao-Li. [Relationship between simulated weightlessness-induced muscle spindle change and muscle atrophy.] [Article in Chinese]. Acta Physiol Sin 2013; 65 (1): 96-100 (in Chinese with English abstract).