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线粒体与细胞Ca2+信号转导

宋亚曼, 卢中秋, 管敏鑫^*

温州医学院Attardi线粒体生物医学研究院，温州 325035；浙江大学生命科学学院，杭州 310058

摘要

已有研究表明，线粒体不仅调控其自身的Ca2+浓度([Ca2+])，还影响着整个细胞(包括内质网/肌质网、质膜和细胞核)的Ca2+信号转导过程。换言之，线粒体使细胞代谢状态和Ca2+转运过程偶联起来。本文详细介绍了线粒体Ca2+调节体系如何整合、调节细胞Ca2+信号，进而促使细胞完成复杂的生命活动；列举了线粒体Ca2+调节过程中亟待解决的问题，并对未来的研究方向提出建议。

关键词： 线粒体; Ca2+; 信号转导; 心肌; 生理学

分类号：Q257；R337

[Mitochondria couple cellular Ca(2+) signal transduction.] [Article in Chinese]

SONG Ya-Man, LU Zhong-Qiu, GUAN Min-Xin^*

Attardi Institute of Mitochondrial Biomedicine, Wenzhou Medical College, Wenzhou 325035, China； College of Life Sciences, Zhejiang University, Hangzhou 310058, China

Abstract

It has been shown that mitochondria not only control their own Ca2+ concentration ([Ca2+]), but also exert an influence over Ca2+ signaling of the entire cell, including the endoplasmic reticulum or the sarcoplasmic reticulum, the plasma membrane, and the nucleus. That is to say, mitochondria couple cellular metabolic state with Ca2+ transport processes. This review focuses on the ways in which the mitochondrial Ca2+ handling system provides integrity and modulation for the cell to cope with the complex actions throughout its life cycle, enumerates some indeterminate aspects about it, and finally, prospects directions of future research.

Key words: Mitochondria; Ca2+; signal transduction; myocardium; physiology

收稿日期：2011-09-21　　录用日期：2012-02-22

通讯作者：管敏鑫　　E-mail: gminxin88@gmail.com

引用本文：

宋亚曼, 卢中秋, 管敏鑫. 线粒体与细胞Ca2+信号转导[J]. 生理学报 2012; 64 (3): 333-340.

SONG Ya-Man, LU Zhong-Qiu, GUAN Min-Xin. [Mitochondria couple cellular Ca(2+) signal transduction.] [Article in Chinese]. Acta Physiol Sin 2012; 64 (3): 333-340 (in Chinese with English abstract).