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心血管缺血再灌注损伤钙调控的研究进展

贺熙, 毕学苑, 王皓, 于晓江, 臧伟进^*

西安交通大学医学院药理学系，西安 710061

摘要

缺血再灌注损伤(ischemia-reperfusion injury, IRI)是治疗缺血性心、脑血管疾病亟待解决的关键问题。钙调控是目前IRI研究中的重要课题。本文就心血管IRI的钙信号调节，包括IRI与钙超载的关系以及IRI与钙敏感性的关系作一综述。其中重点阐述了IRI钙信号调节的关键环节，包括生物膜受损通透性增加使外Ca2+内流增加、Na+-Ca2+交换蛋白逆向转运增强使大量Ca2+摄入细胞、肌浆网Ca2+-ATP酶活性下降导致Ca2+摄取功能障碍、收缩调控蛋白Rho激酶活性增加等。对IRI钙信号调节的关键环节的研究可为临床心血管IRI的防治提供重要策略和潜在靶点。

关键词： 缺血再灌注损伤; 钙超载; 钙敏感性; 心血管系统

分类号：R3

[Protective effects of sodium nitrite preconditioning against alcohol-induced acute liver injury in mice.] [Article in Chinese]

HE Xi, BI Xue-Yuan, WANG Hao, YU Xiao-Jiang, ZANG Wei-Jin^*

Department of Pharmacology, School of Medicine, Xi’an Jiaotong University, Xi’an 710061, China

Abstract

Ischemia-reperfusion injury (IRI) has been recognized as a serious problem for therapy of cardiovascular diseases. Calcium regulation appears to be an important issue in the study of IRI. This article reviews calcium regulation in myocardial and vascular IRI, including the calcium overload and calcium sensitivity in IRI. This review is focused on the key players in Ca2+ handling in IRI, including membrane damage resulting in increase in Ca2+ influx, reverse-mode of Na+-Ca2+ exchangers leading to increased Ca2+ entry, the decreased activity of sarcoplasmic reticulum (SR) Ca2+-ATPase causing SR Ca2+ uptake dysfunction, and increased activity of Rho kinase. These key players in Ca2+ homeostasis will provide promising strategies and potential targets for therapy of cardiovascular IRI.

Key words: ischemia-reperfusion injury; calcium overload; calcium sensitivity; cardiovascular system

收稿日期：2011-11-30　　录用日期：2011-12-29

通讯作者：臧伟进　　E-mail: zwj@mail.xjtu.edu.cn

引用本文：

贺熙, 毕学苑, 王皓, 于晓江, 臧伟进. 心血管缺血再灌注损伤钙调控的研究进展[J]. 生理学报 2012; 64 (3): 321-326.

HE Xi, BI Xue-Yuan, WANG Hao, YU Xiao-Jiang, ZANG Wei-Jin. [Protective effects of sodium nitrite preconditioning against alcohol-induced acute liver injury in mice.] [Article in Chinese]. Acta Physiol Sin 2012; 64 (3): 321-326 (in Chinese with English abstract).