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肥胖者内脂素基因多态性对糖脂代谢及运动减肥效果的影响

赖爱萍^*, 陈文鹤

浙江体育职业技术学院体育系，杭州 311231；上海体育学院运动科学学院，上海 200438

摘要

内脂素(visfatin)，又被称为尼克酰胺磷酸核糖转移酶(nicotinamide phosphoribosyl transferase, NAMPT)，是由脂肪组织分泌的细胞因子，在体内进行免疫调节，还可以作为NAMPT调节NAD+补救途径，同时也可影响糖脂代谢及运动减肥效果。本文旨在对肥胖者内脂素基因多态性与糖脂代谢及运动减肥效果的相关研究进行综述。

关键词： 内脂素; 基因多态性; 糖脂代谢; 运动干预

分类号：G804.7

[Effects of visfatin gene polymorphisms on glycolipid metabolism and exercise-induced weight reduction in obesity.] [Article in Chinese]

LAI Ai-Ping^*, CHEN Wen-He

Physical Education Department of Zhejiang College of Sports, Hangzhou 311231, China； School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China

Abstract

Visfatin, also named nicotinamide phosphoribosyl transferase (NAMPT), is a cytokine secreted from adipose tissue. Visfatin can regulate immune action and is involved in the NAD+ salvage pathway. In addition, recent researches have shown that visfatin helps the regulation of glucose and lipid metabolism, especially in exercise-induced weight reduction for obesity. The aim of this review is to provide an overview of the contribution of visfatin gene polymorphisms to glucose and lipid metabolism and exercise-induced weight reduction in obesity.

Key words: visfatin; gene polymorphisms; glucose and lipid metabolism; exercise

收稿日期：2011-06-03　　录用日期：2011-09-21

通讯作者：赖爱萍　　E-mail: lap810@163.com

引用本文：

赖爱萍, 陈文鹤. 肥胖者内脂素基因多态性对糖脂代谢及运动减肥效果的影响[J]. 生理学报 2012; 64 (1): 96-100.

LAI Ai-Ping, CHEN Wen-He. [Effects of visfatin gene polymorphisms on glycolipid metabolism and exercise-induced weight reduction in obesity.] [Article in Chinese]. Acta Physiol Sin 2012; 64 (1): 96-100 (in Chinese with English abstract).