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中枢α受体在大鼠颈动脉窦反射中的调制作用

黄伟秋, 徐浩东, 吴新, 徐斌, 于志铭

苏州医学院生理学教研室， 苏州 215007

摘要

孤离大鼠左侧颈动脉窦,采用侧脑室（LCV）注射α1受体阻断剂酚苄明（phenoxybenzam-ine PBZ,2μg/20μl）或α2受体阻断剂育亨宾（yohimbine Y,2μg/20μl）,以颈动脉窦内压（ISP）-平均动脉压（MAP）关系曲线及其有关参数为指标,研究和分析了中枢α受体对颈动脉窦反射的影响。将所得ISP和MAP经Logistic方程拟合,建立ISP-MAP关系曲线。结果如下:PBZ组,ISP-MAP关系曲线在高窦内压区明显上移;峰斜率、MAP变动范围明显减小;ISP-斜率关系曲线在15.96kPa处明显下移。Y组,ISP-MAP关系曲线在高窦内压区明显上移;峰斜率、MAP变动范围明显减小,阈压明显增大,ISP-斜率关系曲线在10.64、15.96kPa处明显下移。与PBZ组相比,Y组的峰斜率、MAP变动范围减小更明显。结果表明:中枢α1或α2受体阻断后,窦反射的敏感性明显降低,其中阻断α2受体的作用尤为明显。

关键词： 大鼠; 颈动脉窦反射; 酚苄明; α1受体; 育亨宾; α2受体

Role of the central alpha-receptors in the modulation of carotid sinus reflex of rats

HUANG WeI-Qiu, XU Hao-Dong, WU Xin, Xu Bin, YU Zhi-Ming

Department of Physiology, Suzhou Medical College, Suzhou 215007, China

Abstract

To investigate the effects of the central alpha-receptors on the carotid sinus reflex, phenoxybenzamine (PBZ, 2 micrograms/20 microliters) or yohimbine (Y, 2 micrograms/20 microliters) was injected into the lateral cerebral ventricle (LCV) and intracarotid sinus pressure (ISP)-mean arterial pressure (MAP) relationship curve was constructed and fitted by a Logistic function. The results were as follows: (1) After injection of PBZ into LCV, the ISP-MAP relationship curve shifted upward at a higher ISP level with decreased peak slope and MAP range while the ISP-slope curve shifted downward. (2) After injection of Y into LCV, the ISP-MAP relationship curve shifted upward at a higher ISP level with decreased peak slope and MAP range and increased threshold. The ISP-slope curve shifted downward significantly at 10.64, 15.96 kPa. The peak slope and MAP range of Y group decreased significantly as compared with that of the PBZ group. These results indicated that after blockage of central alpha-receptors the sensitivity of the sinus reflex decreased significantly, and the blockage action of alpha 2-receptor is greater than that of alpha 1-receptor.

Key words: Rat; carotid sinus reflex; phenoxybenzamine; alpha1-receptor; yohimbine; alpha2-receptor

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引用本文：

黄伟秋, 徐浩东, 吴新, 徐斌, 于志铭. 中枢α受体在大鼠颈动脉窦反射中的调制作用[J]. 生理学报 1992; 44 (6): 556-561.

HUANG WeI-Qiu, XU Hao-Dong, WU Xin, Xu Bin, YU Zhi-Ming. Role of the central alpha-receptors in the modulation of carotid sinus reflex of rats. Acta Physiol Sin 1992; 44 (6): 556-561 (in Chinese with English abstract).