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参与不同难度数字计算的脑区-----脑功能磁共振成像研究

张增强, 舒斯云, 刘颂豪, 郭周义, 吴永明, 包新民, 郑金龙, 马翰章

南方医科大学珠江医院神经内科.广东,广州 510280；华南师范大学信息光电子科技学院.广东,广州 510631；南方医科大学南方医院神经内科.广东,广州 510515

摘要

该研究用功能磁共振成像技术观察了人脑进行不同难度数字加减计算时的脑区激活情况,并探讨大脑皮层和皮层下结构在数字计算中的作用。用Siemens 1.5 Tesla磁共振机对16名右利手健康志愿者进行简单及复杂数字加减任务的fMRI扫描。实验采用组块设计。刺激任务分为简单加减计算任务、复杂加减计算任务和基线任务。用SPM99软件进行数据分析和脑功能区定位。分别比较同一任务各个脑区平均激活强度和同一脑区在两种任务中的激活强度。结果显示,简单及复杂加减计算激活的被试者的脑区基本相同,激活的皮层区主要见于额叶、顶叶、枕叶、扣带回、丘脑及小脑;简单及复杂加减计算激活的皮层下结构包括两侧尾状核、左纹状体边缘区等基底核结构和丘脑。在简单及复杂计算中,纹状体与皮质结构(额叶、顶叶)间激活强度均无显著性差异。简单计算与复杂计算比较,右顶叶,在复杂任务时出现激活,在简单任务时未出现激活。上述结果提示,完成数字计算任务的脑区除了额叶、顶叶、扣带回等皮层结构外,大脑皮层下的一些结构如纹状体、纹状体边缘区,也是参与数字计算的重要部位。皮层下结构纹状体和优势半球的纹状体边缘区参与了数字工作记忆,可能是进行数字计算神经环路的重要组成部位。右顶叶(缘上回)只在复杂任务出现激活,该区可能是视空间记忆和加工的重要部位。

关键词： 功能磁共振成像; 数字计算; 皮层及皮层下结构; 纹状体边缘区

Activated brain areas during simple and complex mental calculation-----A functional MRI study

Zhang Zengqiang, Shu Siyun, Liu Songhao, Guo Zhouyi, Wu Yongming, Bao Xinmin, Zheng Jinlong, Ma Hanzhang

Department of Neurology,Zhujiang Hospital Affiliated to Southern Medical University.Guangzhou 510280,Guangdong；China；Department of Neurology,Nanfang Hospital Affiliated to Southern Medical University.Guangzhou 510515,Guangdong

Abstract

Functional magnetic resonance imaging (fMRI) was used to study the activated brain areas of human during simple and complex digital calculation, and to investigate the role of cortical and subcortical structures involved in the mental calculation. Sixteen right-handed healthy volunteers performed mental calculation of simple and complex addition/subtraction respectively, while the fMRI data were recorded by a Seimens 1.5 T MR machine. Block-design was used in the tasks. Two calculation tasks and one base-line tasks were performed for the block-design. Simple calculation task was single-digit addition and subtraction, while the complex was multidigit addition and subtraction. The base-line task was to tell whether the two numbers were the same in every trial. Statistical parametric mapping (SPM99) was employed to process data and localize functional areas. We compared the average activation intensity of each activated brain regions in the same calculation task and the activation intensity of the same regions in both tasks respectively. Both the cortex and the subcortical structures including basal ganglia and thalamus were activated during simple and complex mental calculations. Similar brain regions in subjects including frontal lobe, parietal lobe, occipital lobe, cingulate gyrus, thalamus and cerebellum were engaged in simple and complex addition/subtraction. In the same task, activation intensity of all activated brain areas differedinsignificantly. Compared with the complex task, the right parietal lobe was not activated in the simple one. The subcortical structures such as the caudate nucleus and the left marginal division of the striatum (MrD) were activated in both two calculation tasks. The cortical regions involved in both simple and complex addition/subtraction were similar. In conclusion, both the cortex and the subcortical structures were activated during the mental calculation. The cortex including the frontal cortex, parietal cortex, and cingulate gyrus were activated during mental calculation, while the subcortical structures such as the caudate nucleus, the globus pallidum and the left marginal division of the striatum also played a critical role in the neural networks of the calculation at the same time. Right parietal lobe (supramarginal gyrus) was engaged only in the complex task, which suggested that this region might be involved in the visuospatial memory and processing.

Key words: functional magnetic resonance imaging;mental calculation;cortical and subcortical structures;marginal division of striatum

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引用本文：

张增强, 舒斯云, 刘颂豪, 郭周义, 吴永明, 包新民, 郑金龙, 马翰章. 参与不同难度数字计算的脑区-----脑功能磁共振成像研究[J]. 生理学报 2008; 60 (4): 504-510.

Zhang Zengqiang, Shu Siyun, Liu Songhao, Guo Zhouyi, Wu Yongming, Bao Xinmin, Zheng Jinlong, Ma Hanzhang. Activated brain areas during simple and complex mental calculation-----A functional MRI study. Acta Physiol Sin 2008; 60 (4): 504-510 (in Chinese with English abstract).